2-{4-oxo-5-[4-(1-phenyl-2-(3-nonyloxy-1-phenyl-1,2,3,4-tetrahydroquinolin-6-methy-lene)hydrazinyl)benzylidene]-2-thioxothiazolidin-3-yl}acetic acid

Base Information

Chemical Name:2-{4-oxo-5-[4-(1-phenyl-2-(3-nonyloxy-1-phenyl-1,2,3,4-tetrahydroquinolin-6-methy-lene)hydrazinyl)benzylidene]-2-thioxothiazolidin-3-yl}acetic acid
CAS No.:1564287-81-5
Molecular Formula:C₄₃H₄₆N₄O₄S₂
Molecular Weight:746.995
Hs Code.:

2-{4-oxo-5-[4-(1-phenyl-2-(3-nonyloxy-1-phenyl-1,2,3,4-tetrahydroquinolin-6-methy-lene)hydrazinyl)benzylidene]-2-thioxothiazolidin-3-yl}acetic acid

Synonyms:2-{4-oxo-5-[4-(1-phenyl-2-(3-nonyloxy-1-phenyl-1,2,3,4-tetrahydroquinolin-6-methy-lene)hydrazinyl)benzylidene]-2-thioxothiazolidin-3-yl}acetic acid

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Chemical Property of 2-{4-oxo-5-[4-(1-phenyl-2-(3-nonyloxy-1-phenyl-1,2,3,4-tetrahydroquinolin-6-methy-lene)hydrazinyl)benzylidene]-2-thioxothiazolidin-3-yl}acetic acid

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Technology Process of 2-{4-oxo-5-[4-(1-phenyl-2-(3-nonyloxy-1-phenyl-1,2,3,4-tetrahydroquinolin-6-methy-lene)hydrazinyl)benzylidene]-2-thioxothiazolidin-3-yl}acetic acid

There total 5 articles about 2-{4-oxo-5-[4-(1-phenyl-2-(3-nonyloxy-1-phenyl-1,2,3,4-tetrahydroquinolin-6-methy-lene)hydrazinyl)benzylidene]-2-thioxothiazolidin-3-yl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.1%

: 5718-83-2
rhodanine 3-acetic acid

: 1564287-78-0
3-nonyloxy-1-phenyl-1,2,3,4-tetrahydroquinoline-6-carbaldehyde N-(4-formyl)phenyl-N-phenylhydrazone

: 1564287-81-5
2-{4-oxo-5-[4-(1-phenyl-2-(3-nonyloxy-1-phenyl-1,2,3,4-tetrahydroquinolin-6-methy-lene)hydrazinyl)benzylidene]-2-thioxothiazolidin-3-yl}acetic acid

Guidance literature:: With ammonium acetate; In acetic acid; at 100 ℃; for 2h;
DOI:10.1016/j.dyepig.2014.01.010

Reference yield:

: 3297-78-7
acetic acid 1-phenyl-1,2,3,4-tetrahydro-quinolin-3-yl ester

: 1564287-81-5
2-{4-oxo-5-[4-(1-phenyl-2-(3-nonyloxy-1-phenyl-1,2,3,4-tetrahydroquinolin-6-methy-lene)hydrazinyl)benzylidene]-2-thioxothiazolidin-3-yl}acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: trichlorophosphate

2: potassium hydroxide / methanol; water / 0.58 h / Reflux

3: potassium hydroxide; sodium sulfate / N,N-dimethyl-formamide / 60 - 65 °C

4: isopropyl alcohol / 3 h / 85 °C

5: potassium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

6: ammonium acetate / acetic acid / 2 h / 100 °C

With ammonium acetate; potassium carbonate; sodium sulfate; potassium hydroxide; trichlorophosphate; In methanol; water; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; 1: |Vilsmeier-Haack Formylation / 6: |Knoevenagel Condensation;
DOI:10.1016/j.dyepig.2014.01.010

Reference yield:

: 934420-64-1
3-acetyl-1-phenyl-1,2,3,4-tetrahydroquinoline-6-carbaldehyde

: 1564287-81-5
2-{4-oxo-5-[4-(1-phenyl-2-(3-nonyloxy-1-phenyl-1,2,3,4-tetrahydroquinolin-6-methy-lene)hydrazinyl)benzylidene]-2-thioxothiazolidin-3-yl}acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hydroxide / methanol; water / 0.58 h / Reflux

2: potassium hydroxide; sodium sulfate / N,N-dimethyl-formamide / 60 - 65 °C

3: isopropyl alcohol / 3 h / 85 °C

4: potassium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

5: ammonium acetate / acetic acid / 2 h / 100 °C

With ammonium acetate; potassium carbonate; sodium sulfate; potassium hydroxide; In methanol; water; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; 5: |Knoevenagel Condensation;
DOI:10.1016/j.dyepig.2014.01.010