4-(4-chlorobenzoyl)-5-methyl-2-(p-tolyl)-2,4-dihydro-3H-pyrazol-3-one

Base Information

• Chemical Name: 4-(4-chlorobenzoyl)-5-methyl-2-(p-tolyl)-2,4-dihydro-3H-pyrazol-3-one
• CAS No.: 151512-62-8
• Molecular Formula: C₁₈H₁₅ClN₂O₂
• Molecular Weight: 326.782
• Mol file: 151512-62-8.mol

Synonyms:4-(4-chlorobenzoyl)-5-methyl-2-(p-tolyl)-2,4-dihydro-3H-pyrazol-3-one

Chemical Property of 4-(4-chlorobenzoyl)-5-methyl-2-(p-tolyl)-2,4-dihydro-3H-pyrazol-3-one

Chemical Property:

Purity/Quality:

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Technology Process of 4-(4-chlorobenzoyl)-5-methyl-2-(p-tolyl)-2,4-dihydro-3H-pyrazol-3-one

There total 1 articles about 4-(4-chlorobenzoyl)-5-methyl-2-(p-tolyl)-2,4-dihydro-3H-pyrazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-chloro-benzoyl chloride (122-01-0) + 3-methyl-1-(4-methylphenyl)-2-pyrazolin-5-one (86-92-0) → 4-(4-chlorobenzoyl)-5-methyl-2-(p-tolyl)-2,4-dihydro-3H-pyrazol-3-one (151512-62-8)

Guidance literature:

3-methyl-1-(4-methylphenyl)-2-pyrazolin-5-one; In 1,4-dioxane; at 80 ℃; for 0.25h;

With calcium hydroxide; In 1,4-dioxane; for 0.166667h;

4-chloro-benzoyl chloride; In 1,4-dioxane; for 3h; Reflux;

DOI:10.1016/j.poly.2020.114528

Reference yield: 86.7%

1,10-Phenanthroline (66-71-7) + 4-(4-chlorobenzoyl)-5-methyl-2-(p-tolyl)-2,4-dihydro-3H-pyrazol-3-one (151512-62-8) + zinc diacetate (557-34-6) → C48H36Cl2N6O4Zn

Guidance literature:

4-(4-chlorobenzoyl)-5-methyl-2-(p-tolyl)-2,4-dihydro-3H-pyrazol-3-one; zinc diacetate; In methanol; for 0.5h;

1,10-Phenanthroline; With sodium acetate; In methanol; for 4h; Reflux;

DOI:10.1016/j.poly.2020.114528

Reference yield: 85.2%

[2,2]bipyridinyl (366-18-7) + 4-(4-chlorobenzoyl)-5-methyl-2-(p-tolyl)-2,4-dihydro-3H-pyrazol-3-one (151512-62-8) + zinc diacetate (557-34-6) → C46H36Cl2N6O4Zn

Guidance literature:

4-(4-chlorobenzoyl)-5-methyl-2-(p-tolyl)-2,4-dihydro-3H-pyrazol-3-one; zinc diacetate; In methanol; for 0.5h;

[2,2]bipyridinyl; With sodium acetate; In methanol; for 4h; Reflux;

DOI:10.1016/j.poly.2020.114528

upstream raw materials:

4-chloro-benzoyl chloride

3-methyl-1-(4-methylphenyl)-2-pyrazolin-5-one