C₂₀H₂₂N₄O₄S

Base Information

• Chemical Name: C₂₀H₂₂N₄O₄S
• CAS No.: 1443745-66-1
• Molecular Formula: C₂₀H₂₂N₄O₄S
• Molecular Weight: 414.485
• Mol file: 1443745-66-1.mol

Synonyms:C₂₀H₂₂N₄O₄S

Chemical Property of C₂₀H₂₂N₄O₄S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₂N₄O₄S

There total 4 articles about C₂₀H₂₂N₄O₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

4-piperidinemethanol hydrochloride (90748-01-9) + 5-amino-3,4-dihydro-3-(4-methoxyphenyl)-4-oxo-thieno[3,4-d]pyridazine-1-carboxylic acid (222164-34-3) → C20H22N4O4S (1443745-66-1)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 20 ℃; for 16h;

Reference yield:

4-methoxy-aniline (104-94-9) → C20H22N4O4S (1443745-66-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogenchloride; sodium nitrite / ethanol; water / 0.33 h / 0 °C

1.2: 2 h / 0 °C

2.1: ammonium acetate; acetic acid / 0.75 h / 120 °C / Microwave irradiation

3.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 16 h / 20 °C

3.2: pH 6

4.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dimethyl sulfoxide / 16 h / 20 °C

With hydrogenchloride; lithium hydroxide monohydrate; ammonium acetate; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide;

Reference yield:

ethyl 5-cyano-1-(4-methoxyphenyl)-4-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate (123565-82-2) → C20H22N4O4S (1443745-66-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 16 h / 20 °C

1.2: pH 6

2.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dimethyl sulfoxide / 16 h / 20 °C

With lithium hydroxide monohydrate; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dimethyl sulfoxide;

upstream raw materials:

4-piperidinemethanol hydrochloride

5-amino-3,4-dihydro-3-(4-methoxyphenyl)-4-oxo-thieno[3,4-d]pyridazine-1-carboxylic acid

4-methoxy-aniline

3-oxo-2-(2-(4-methoxyphenyl)hydrazono)butanoic acid ethyl ester

Downstream raw materials:

C₂₀H₂₁FN₄O₃S