dimethyl 4-phenyl-1-(4-methoxyphenyl)-2,4-dihydro-1H-pyrrole-2,3-dicarboxylate

Base Information

• Chemical Name: dimethyl 4-phenyl-1-(4-methoxyphenyl)-2,4-dihydro-1H-pyrrole-2,3-dicarboxylate
• CAS No.: 1189054-24-7
• Molecular Formula: C₂₁H₂₁NO₅
• Molecular Weight: 367.401
• Mol file: 1189054-24-7.mol

Synonyms:dimethyl 4-phenyl-1-(4-methoxyphenyl)-2,4-dihydro-1H-pyrrole-2,3-dicarboxylate

Chemical Property of dimethyl 4-phenyl-1-(4-methoxyphenyl)-2,4-dihydro-1H-pyrrole-2,3-dicarboxylate

Chemical Property:

Purity/Quality:

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Technology Process of dimethyl 4-phenyl-1-(4-methoxyphenyl)-2,4-dihydro-1H-pyrrole-2,3-dicarboxylate

There total 4 articles about dimethyl 4-phenyl-1-(4-methoxyphenyl)-2,4-dihydro-1H-pyrrole-2,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-((4-methoxyphenyl)amino)-1-phenylethanone (5883-82-9) + dimethyl acetylenedicarboxylate (762-42-5) → dimethyl 4-phenyl-1-(4-methoxyphenyl)-2,4-dihydro-1H-pyrrole-2,3-dicarboxylate (1189054-24-7)

Guidance literature:

With triphenylphosphine; In dichloromethane; at 20 ℃;

DOI:10.1055/s-0029-1217516

Reference yield: 85.0%

2-((4-methoxyphenyl)amino)-1-phenylethanone (5883-82-9) + dimethyl acetylenedicarboxylate (762-42-5) → dimethyl 4-phenyl-1-(4-methoxyphenyl)-2,4-dihydro-1H-pyrrole-2,3-dicarboxylate (1189054-24-7) + 1-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,3-dicarboxylic acid dimethyl ester (22050-14-2)

Guidance literature:

With triphenylphosphine; In toluene; for 72h; Inert atmosphere; Schlenk technique; Reflux;

DOI:10.1002/ejoc.202100404

Reference yield:

4-methoxy-aniline (104-94-9) → dimethyl 4-phenyl-1-(4-methoxyphenyl)-2,4-dihydro-1H-pyrrole-2,3-dicarboxylate (1189054-24-7) + 1-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,3-dicarboxylic acid dimethyl ester (22050-14-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / ethanol / 20 °C / Inert atmosphere

2: triphenylphosphine / toluene / 72 h / Inert atmosphere; Schlenk technique; Reflux

With sodium carbonate; triphenylphosphine; In ethanol; toluene;

DOI:10.1002/ejoc.202100404

upstream raw materials:

2-((4-methoxyphenyl)amino)-1-phenylethanone

dimethyl acetylenedicarboxylate

α-bromoacetophenone

4-methoxy-aniline

Downstream raw materials:

1-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,3-dicarboxylic acid dimethyl ester