ethyl 4-(1-benzyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxylate

Base Information

• Chemical Name: ethyl 4-(1-benzyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxylate
• CAS No.: 1350917-93-9
• Molecular Formula: C₂₂H₃₀N₄O₃Si
• Molecular Weight: 426.591
• Mol file: 1350917-93-9.mol

Synonyms:ethyl 4-(1-benzyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxylate

Chemical Property of ethyl 4-(1-benzyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-(1-benzyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxylate

There total 4 articles about ethyl 4-(1-benzyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

1-(phenylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (761446-45-1) + ethyl 4-bromo-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-imidazole-2-carboxylate (954125-17-8) → ethyl 4-(1-benzyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxylate (1350917-93-9)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 110 ℃; for 1h; Inert atmosphere; Microwave irradiation;

Reference yield:

(2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) → ethyl 4-(1-benzyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxylate (1350917-93-9)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

2: N-Bromosuccinimide / dichloromethane; N,N-dimethyl-formamide / 20 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 1 h / 110 °C / Inert atmosphere; Microwave irradiation

With N-Bromosuccinimide; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

ethyl 1H-imidazole-2-carboxylate (33543-78-1) → ethyl 4-(1-benzyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxylate (1350917-93-9)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

2: N-Bromosuccinimide / dichloromethane; N,N-dimethyl-formamide / 20 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 1 h / 110 °C / Inert atmosphere; Microwave irradiation

With N-Bromosuccinimide; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

upstream raw materials:

ethyl 1H-imidazole-2-carboxylate

(2-trimethylethylsilylethoxy)methyl chloride

1-(phenylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

ethyl 4-bromo-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-imidazole-2-carboxylate

Downstream raw materials:

N-{2-[(3R)-3-amino-1-piperidinyl]-3-fluorophenyl}-4-(1-(phenylmethyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide

(R)-tert-butyl 1-(2-(4-(1-benzyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)-6-fluorophenyl)piperidin-3-ylcarbamate

lithium 4-(1-benzyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxylate

N-(2-(2-(dimethylamino)ethoxy)phenyl)-4-(1-(phenylmetyl)-1H-pyrazol-4-yl)-1H-imidazole-2-carboxamide