Technology Process of ethyl 1-benzyl-5-(tert-butoxycarbonylamino)-4-oxo-1,4-dihydropyridine-3-carboxylate
There total 5 articles about ethyl 1-benzyl-5-(tert-butoxycarbonylamino)-4-oxo-1,4-dihydropyridine-3-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-benzyl-5-(ethoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid;
With
4-methyl-morpholine; chloroformic acid ethyl ester;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at 0 ℃;
for 0.416667h;
With
sodium azide;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
for 0.5h;
tert-butyl alcohol;
In
toluene;
at 90 ℃;
for 30h;
DOI:10.1021/ja206457b
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium hydroxide / ethanol / 20 °C
2.1: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran; N,N-dimethyl-formamide / 0.42 h / 0 °C
2.2: 0.5 h
2.3: 30 h / 90 °C
With
4-methyl-morpholine; chloroformic acid ethyl ester; potassium hydroxide;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ja206457b
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 80 °C
2.1: potassium hydroxide / ethanol / 20 °C
3.1: 4-methyl-morpholine; chloroformic acid ethyl ester / tetrahydrofuran; N,N-dimethyl-formamide / 0.42 h / 0 °C
3.2: 0.5 h
3.3: 30 h / 90 °C
With
4-methyl-morpholine; chloroformic acid ethyl ester; potassium carbonate; potassium hydroxide;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ja206457b