ethyl 4-[5-fluoro-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}-2-(methyloxy)phenyl]butanoate

Base Information

Chemical Name:ethyl 4-[5-fluoro-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}-2-(methyloxy)phenyl]butanoate
CAS No.:1334607-88-3
Molecular Formula:C₂₇H₂₈F₄N₂O₄
Molecular Weight:520.524
Hs Code.:

Synonyms:ethyl 4-[5-fluoro-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}-2-(methyloxy)phenyl]butanoate

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Chemical Property of ethyl 4-[5-fluoro-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}-2-(methyloxy)phenyl]butanoate

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Technology Process of ethyl 4-[5-fluoro-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}-2-(methyloxy)phenyl]butanoate

There total 10 articles about ethyl 4-[5-fluoro-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}-2-(methyloxy)phenyl]butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 179897-92-8
1-bromo-5-fluoro-2-(methyloxy)-3-nitrobenzene

: 1334607-88-3
ethyl 4-[5-fluoro-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}-2-(methyloxy)phenyl]butanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate; tri-tert-butyl phosphine / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran / 20 °C / Inert atmosphere

2.1: ammonium chloride; iron / 90 °C

3.1: sodium nitrite; hydrogen bromide / acetonitrile; water / 0.17 h / 0 °C

3.2: 1 h / 50 °C

4.1: tricyclohexylphosphine; potassium acetate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.75 h / 150 °C / Inert atmosphere; Sealed; Microwave irradiation

5.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Microwave irradiation

6.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Microwave irradiation

With potassium phosphate; tri-tert-butyl phosphine; hydrogen bromide; potassium acetate; iron; ammonium chloride; caesium carbonate; sodium nitrite; tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1334607-79-2
4,4,5,5-tetramethyl-2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,3,2-dioxaborolane

: 1334607-87-2
ethyl 4-[3-(2-chloro-5-pyrimidinyl)-5-fluoro-2-(methyloxy)phenyl]butanoate

: 1334607-88-3
ethyl 4-[5-fluoro-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}-2-(methyloxy)phenyl]butanoate

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 120 ℃; for 0.25h; Inert atmosphere; Sealed; Microwave irradiation;

Reference yield:

: 452-08-4
2-bromo-4-fluoro-1-methoxybenzene

: 1334607-88-3
ethyl 4-[5-fluoro-3-{2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-5-pyrimidinyl}-2-(methyloxy)phenyl]butanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: nitric acid; sulfuric acid / 0.5 h / -10 °C

2.1: caesium carbonate; tri-tert-butyl phosphine / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran / 20 °C / Inert atmosphere

3.1: ammonium chloride; iron / 90 °C

4.1: sodium nitrite; hydrogen bromide / acetonitrile; water / 0.17 h / 0 °C

4.2: 1 h / 50 °C

5.1: tricyclohexylphosphine; potassium acetate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.75 h / 150 °C / Inert atmosphere; Sealed; Microwave irradiation

6.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Microwave irradiation

7.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Microwave irradiation

With potassium phosphate; tri-tert-butyl phosphine; sulfuric acid; hydrogen bromide; nitric acid; potassium acetate; iron; ammonium chloride; caesium carbonate; sodium nitrite; tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetonitrile;