2-<2-(5-methyl-4-imidazolylmethylthio)ethylamino>-5-(4-methoxybenzyl)pyrimidin-4-thione dihydrochloride

Base Information

Chemical Name:2-<2-(5-methyl-4-imidazolylmethylthio)ethylamino>-5-(4-methoxybenzyl)pyrimidin-4-thione dihydrochloride
CAS No.:70330-53-9
Molecular Formula:C₁₉H₂₃N₅OS₂*2ClH
Molecular Weight:474.478
Hs Code.:

Synonyms:2-<2-(5-methyl-4-imidazolylmethylthio)ethylamino>-5-(4-methoxybenzyl)pyrimidin-4-thione dihydrochloride

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Chemical Property of 2-<2-(5-methyl-4-imidazolylmethylthio)ethylamino>-5-(4-methoxybenzyl)pyrimidin-4-thione dihydrochloride

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Technology Process of 2-<2-(5-methyl-4-imidazolylmethylthio)ethylamino>-5-(4-methoxybenzyl)pyrimidin-4-thione dihydrochloride

There total 7 articles about 2-<2-(5-methyl-4-imidazolylmethylthio)ethylamino>-5-(4-methoxybenzyl)pyrimidin-4-thione dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 63204-17-1
2-<2-(5-methyl-4-imidazolylmethylthio)ethylamino>-5-(4-methoxybenzyl)pyrimidin-4-thione dihydrochloride

: 70330-53-9
2-<2-(5-methyl-4-imidazolylmethylthio)ethylamino>-5-(4-methoxybenzyl)pyrimidin-4-thione dihydrochloride

Guidance literature:: With diphosphorus pentasulfide; In pyridine; for 7h; Heating;
DOI:10.1016/0223-5234(88)90167-5

Reference yield:

: 24393-56-4
ethyl (E)-3-(4-methoxyphenyl)prop-2-enoate

: 70330-53-9
2-<2-(5-methyl-4-imidazolylmethylthio)ethylamino>-5-(4-methoxybenzyl)pyrimidin-4-thione dihydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogen / 5percent Pd/C / ethanol

2: sodium wire / diethyl ether / 18 h / Ambient temperature

3: ethanol / 7 h / Heating

4: 71 percent / aq. NaOH / ethanol / 60 °C

5: 64 percent / 5 h / 140 - 150 °C

6: 39 percent / phosphorus pentasulfide / pyridine / 7 h / Heating

With diphosphorus pentasulfide; sodium hydroxide; hydrogen; sodium; palladium on activated charcoal; In pyridine; diethyl ether; ethanol;
DOI:10.1016/0223-5234(88)90167-5

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 70330-53-9
2-<2-(5-methyl-4-imidazolylmethylthio)ethylamino>-5-(4-methoxybenzyl)pyrimidin-4-thione dihydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: 1) piperidine, 2) conc. H₂SO₄ / 1) pyridine

2: hydrogen / 5percent Pd/C / ethanol

3: sodium wire / diethyl ether / 18 h / Ambient temperature

4: ethanol / 7 h / Heating

5: 71 percent / aq. NaOH / ethanol / 60 °C

6: 64 percent / 5 h / 140 - 150 °C

7: 39 percent / phosphorus pentasulfide / pyridine / 7 h / Heating

With piperidine; diphosphorus pentasulfide; sodium hydroxide; sulfuric acid; hydrogen; sodium; palladium on activated charcoal; In pyridine; diethyl ether; ethanol;
DOI:10.1016/0223-5234(88)90167-5