1-[[5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indolin-1-yl]carbonylmethyl]-3-azetidinecarboxylic acid methyl ester

Base Information

Chemical Name:1-[[5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indolin-1-yl]carbonylmethyl]-3-azetidinecarboxylic acid methyl ester
CAS No.:957204-52-3
Molecular Formula:C₂₇H₂₅F₃N₂O₄S
Molecular Weight:530.568
Hs Code.:

Synonyms:1-[[5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indolin-1-yl]carbonylmethyl]-3-azetidinecarboxylic acid methyl ester

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Chemical Property of 1-[[5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indolin-1-yl]carbonylmethyl]-3-azetidinecarboxylic acid methyl ester

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Technology Process of 1-[[5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indolin-1-yl]carbonylmethyl]-3-azetidinecarboxylic acid methyl ester

There total 1 articles about 1-[[5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indolin-1-yl]carbonylmethyl]-3-azetidinecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100202-39-9
methyl 3-azetidinecarboxylate hydrochloride

: 957203-93-9
5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indoline hydrochloride

: 79-04-9
chloroacetyl chloride

: 957204-52-3
1-[[5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indolin-1-yl]carbonylmethyl]-3-azetidinecarboxylic acid methyl ester

Guidance literature:: 5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indoline hydrochloride; chloroacetyl chloride; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 ℃; for 1h;

methyl 3-azetidinecarboxylate hydrochloride; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 50 ℃; for 2h;

Reference yield:

: 957204-52-3
1-[[5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indolin-1-yl]carbonylmethyl]-3-azetidinecarboxylic acid methyl ester

: 957202-58-3
1-[[5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indolin-1-yl]carbonylmethyl]-3-azetidinecarboxylic acid

Guidance literature:: 1-[[5-[(4-phenyl-5-trifluoromethyl-2-thienyl)methoxy]indolin-1-yl]carbonylmethyl]-3-azetidinecarboxylic acid methyl ester; With sodium hydroxide; water; In tetrahydrofuran; for 1.5h;

With hydrogenchloride; In tetrahydrofuran; water;