3-acetylphenyl pivalate

Base Information

• Chemical Name: 3-acetylphenyl pivalate
• CAS No.: 35086-46-5
• Molecular Formula: C₁₃H₁₆O₃
• Molecular Weight: 220.268
• Mol file: 35086-46-5.mol

Synonyms:3-acetylphenyl pivalate

Chemical Property of 3-acetylphenyl pivalate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 3-acetylphenyl pivalate

There total 2 articles about 3-acetylphenyl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-Hydroxyacetophenone (121-71-1) + pivaloyl chloride (3282-30-2) → 3-acetylphenyl pivalate (35086-46-5)

Guidance literature:

3-Hydroxyacetophenone; With sodium hydride; In tetrahydrofuran; for 0.5h; Inert atmosphere;

pivaloyl chloride; In tetrahydrofuran; for 2h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.5b01677

Reference yield:

→ 3-acetylphenyl pivalate (35086-46-5)

Guidance literature:

(CH3)3COCl, 3-Acetylphenol, Benzol/Pyridin;

Reference yield: 63.0%

1-propyl-2'-thiopyridine (26891-63-4) + 3-acetylphenyl pivalate (35086-46-5) → 1-(3-(propylthio)phenyl)ethan-1-one

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; 3,4-thiene-2,3-diylbis(dicyclohexylphosphine); zinc; In toluene; at 150 ℃; for 24h; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1021/jacs.1c04215

upstream raw materials:

3-Hydroxyacetophenone

pivaloyl chloride

Downstream raw materials:

2,2-Dimethyl-propionic acid 3-(2-bromo-acetyl)-phenyl ester

2-acetylamino-2-{2-[3-(2,2-dimethyl-propionyloxy)-phenyl]-2-oxo-ethyl}-malonic acid diethyl ester

C₁₇H₂₈O₃Si