tert-butyl 2-(2-(4-chloro-3-methoxyphenyl)-2-methylpropanoyl)hydrazine carboxylate

Base Information

Chemical Name:tert-butyl 2-(2-(4-chloro-3-methoxyphenyl)-2-methylpropanoyl)hydrazine carboxylate
CAS No.:1239964-47-6
Molecular Formula:C₁₆H₂₃ClN₂O₄
Molecular Weight:342.823
Hs Code.:

Synonyms:tert-butyl 2-(2-(4-chloro-3-methoxyphenyl)-2-methylpropanoyl)hydrazine carboxylate

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Chemical Property of tert-butyl 2-(2-(4-chloro-3-methoxyphenyl)-2-methylpropanoyl)hydrazine carboxylate

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Technology Process of tert-butyl 2-(2-(4-chloro-3-methoxyphenyl)-2-methylpropanoyl)hydrazine carboxylate

There total 4 articles about tert-butyl 2-(2-(4-chloro-3-methoxyphenyl)-2-methylpropanoyl)hydrazine carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 870-46-2
t-butoxycarbonylhydrazine

: 1239963-78-0
2-(4-chloro-3-methoxyphenyl)-2-methylpropanoic acid

: 1239964-47-6
tert-butyl 2-(2-(4-chloro-3-methoxyphenyl)-2-methylpropanoyl)hydrazine carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 15h;

Reference yield:

: 850564-15-7
2-(4-Chloro-3-methoxy-phenyl)-2-methyl-propionitrile

: 1239964-47-6
tert-butyl 2-(2-(4-chloro-3-methoxyphenyl)-2-methylpropanoyl)hydrazine carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / 20 h / Reflux

2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 15 h

With sulfuric acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

: 16817-43-9
5-Bromo-2-chloroanisole

: 1239964-47-6
tert-butyl 2-(2-(4-chloro-3-methoxyphenyl)-2-methylpropanoyl)hydrazine carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; N-cyclohexyl-cyclohexanamine / toluene; hexane / 0.33 h / 0 - 15 °C / Inert atmosphere

1.2: 25 °C / Inert atmosphere

2.1: potassium trimethylsilonate / tert-butyl methyl ether; tetrahydrofuran / 2 h / 50 °C / Inert atmosphere

2.2: pH 1

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 15 h

With n-butyllithium; potassium trimethylsilonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; N-cyclohexyl-cyclohexanamine; In tetrahydrofuran; hexane; dichloromethane; tert-butyl methyl ether; toluene;