Methanesulfonic acid (R)-1-[(R)-2-cyclohexyl-1-(tetrahydro-pyran-2-yloxycarbamoyl)-ethyl]-butyl ester

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Chemical Name:Methanesulfonic acid (R)-1-[(R)-2-cyclohexyl-1-(tetrahydro-pyran-2-yloxycarbamoyl)-ethyl]-butyl ester
CAS No.:212610-27-0
Molecular Formula:C₁₉H₃₅NO₆S
Molecular Weight:405.556
Hs Code.:

Synonyms:Methanesulfonic acid (R)-1-[(R)-2-cyclohexyl-1-(tetrahydro-pyran-2-yloxycarbamoyl)-ethyl]-butyl ester

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Chemical Property of Methanesulfonic acid (R)-1-[(R)-2-cyclohexyl-1-(tetrahydro-pyran-2-yloxycarbamoyl)-ethyl]-butyl ester

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Technology Process of Methanesulfonic acid (R)-1-[(R)-2-cyclohexyl-1-(tetrahydro-pyran-2-yloxycarbamoyl)-ethyl]-butyl ester

There total 5 articles about Methanesulfonic acid (R)-1-[(R)-2-cyclohexyl-1-(tetrahydro-pyran-2-yloxycarbamoyl)-ethyl]-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124-63-0
methanesulfonyl chloride

: 212610-25-8
(2R,3R)-2-cyclohexylmethyl-3-hydroxyhexanoic acid 2-tetrahydropyranyloxyamide

: 212610-27-0
Methanesulfonic acid (R)-1-[(R)-2-cyclohexyl-1-(tetrahydro-pyran-2-yloxycarbamoyl)-ethyl]-butyl ester

Guidance literature:: With pyridine; In dichloromethane; at 0 ℃;
DOI:10.1021/jm0102654

Reference yield:

: 6723-30-4
O-2-tetrahydro-2H-pyranhydroxylamine

: 212610-27-0
Methanesulfonic acid (R)-1-[(R)-2-cyclohexyl-1-(tetrahydro-pyran-2-yloxycarbamoyl)-ethyl]-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: DCC / ethyl acetate / 0 - 20 °C

2: pyridine / CH₂Cl₂ / 0 °C

With pyridine; dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate;
DOI:10.1021/jm0102654

Reference yield:

: 109053-86-3
methyl (3R)-3-hydroxyhexanoate

: 212610-27-0
Methanesulfonic acid (R)-1-[(R)-2-cyclohexyl-1-(tetrahydro-pyran-2-yloxycarbamoyl)-ethyl]-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 45 percent / LDA; DMPU / tetrahydrofuran / -78 - 0 °C

2: aq. LiOH / tetrahydrofuran; methanol / 24 h

3: DCC / ethyl acetate / 0 - 20 °C

4: pyridine / CH₂Cl₂ / 0 °C

With pyridine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium hydroxide; dicyclohexyl-carbodiimide; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; 1: Frater-Seebach alkylation;
DOI:10.1021/jm0102654