4-(1,3-Diphenyl-1H-pyrazol-4-yl)-6-phenyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile

Base Information

• Chemical Name: 4-(1,3-Diphenyl-1H-pyrazol-4-yl)-6-phenyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile
• CAS No.: 221619-49-4
• Molecular Formula: C₂₇H₁₈N₄S
• Molecular Weight: 430.533

Synonyms:4-(1,3-Diphenyl-1H-pyrazol-4-yl)-6-phenyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile

Chemical Property of 4-(1,3-Diphenyl-1H-pyrazol-4-yl)-6-phenyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile

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Technology Process of 4-(1,3-Diphenyl-1H-pyrazol-4-yl)-6-phenyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile

There total 1 articles about 4-(1,3-Diphenyl-1H-pyrazol-4-yl)-6-phenyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

Cyanothioacetamide (7357-70-2) + 1-phenyl-3-(1,3-diphenyl-1H-pyrazole-4-yl)prop-2-en-1-one (144118-63-8) → 4-(1,3-Diphenyl-1H-pyrazol-4-yl)-6-phenyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile (221619-49-4)

Guidance literature:

In ethanol; Reflux;

DOI:10.1080/00397911.2020.1743318

Reference yield: 84.0%

5-(chloromethyl)salicylaldehyde (23731-06-8) + 4-(1,3-Diphenyl-1H-pyrazol-4-yl)-6-phenyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile (221619-49-4) → C35H24N4O2S

Guidance literature:

4-(1,3-Diphenyl-1H-pyrazol-4-yl)-6-phenyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile; With potassium hydroxide; In ethanol; at 20 ℃; for 0.166667h; Green chemistry;

5-(chloromethyl)salicylaldehyde; In ethanol; at 20 ℃; for 3h; Green chemistry;

DOI:10.1080/00397911.2020.1743318

Reference yield: 80.0%

α-bromoacetophenone (70-11-1) + 4-(1,3-Diphenyl-1H-pyrazol-4-yl)-6-phenyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile (221619-49-4) → 4-(1,3-Diphenyl-1H-pyrazol-4-yl)-2-(2-oxo-2-phenyl-ethylsulfanyl)-6-phenyl-nicotinonitrile

Guidance literature:

With sodium acetate; In ethanol; for 2h; Heating;

upstream raw materials:

Cyanothioacetamide

1-phenyl-3-(1,3-diphenyl-1H-pyrazole-4-yl)prop-2-en-1-one

Downstream raw materials:

[3-Cyano-4-(1,3-diphenyl-1H-pyrazol-4-yl)-6-phenyl-pyridin-2-ylsulfanyl]-acetic acid ethyl ester

2-[3-Cyano-4-(1,3-diphenyl-1H-pyrazol-4-yl)-6-phenyl-pyridin-2-ylsulfanyl]-acetamide

3-Amino-4-(1,3-diphenyl-1H-pyrazol-4-yl)-6-phenyl-thieno[2,3-b]pyridine-2-carboxylic acid amide

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