N-benzyloxycarbonyl-(S)-2-amino-3-(dimethylamino)propanoic acid

Base Information

• Chemical Name: N-benzyloxycarbonyl-(S)-2-amino-3-(dimethylamino)propanoic acid
• CAS No.: 160885-19-8
• Molecular Formula: C₁₃H₁₈N₂O₄
• Molecular Weight: 266.297
• Mol file: 160885-19-8.mol

Synonyms:N-benzyloxycarbonyl-(S)-2-amino-3-(dimethylamino)propanoic acid

Chemical Property of N-benzyloxycarbonyl-(S)-2-amino-3-(dimethylamino)propanoic acid

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N-benzyloxycarbonyl-(S)-2-amino-3-(dimethylamino)propanoic acid

There total 4 articles about N-benzyloxycarbonyl-(S)-2-amino-3-(dimethylamino)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N,N-Dimethyltrimethylsilylamine (2083-91-2) + ((S)-2-Oxo-oxetan-3-yl)-carbamic acid benzyl ester (26054-60-4) → N-benzyloxycarbonyl-(S)-2-amino-3-(dimethylamino)propanoic acid (160885-19-8)

Guidance literature:

In acetonitrile; at 20 ℃; for 2h;

DOI:10.1016/S0040-4039(00)78354-7

Reference yield: 68.0%

N-(benzyloxycarbonyl)-L-serine (1145-80-8) + dimethyl amine (124-40-3) → N-benzyloxycarbonyl-(S)-2-amino-3-(dimethylamino)propanoic acid (160885-19-8)

Guidance literature:

N-(benzyloxycarbonyl)-L-serine; With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at -78 - 20 ℃; for 3h;

dimethyl amine; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2007.01.149

Reference yield:

(S)-2-Benzyloxycarbonylamino-3-dimethylamino-propionic acid methyl ester → N-benzyloxycarbonyl-(S)-2-amino-3-(dimethylamino)propanoic acid (160885-19-8)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 2h;

DOI:10.1080/00304940109356605

upstream raw materials:

N,N-Dimethyltrimethylsilylamine

((S)-2-Oxo-oxetan-3-yl)-carbamic acid benzyl ester

formaldehyd

(S)-3-amino-2-(((benzyloxy)carbonyl)amino)propanoic acid