(-)-(4S,4'S,5S,5'S)-4,4',5,5'-Tetrahydro-2,2'-methylene-5,5'-diphenylbis-4,4'-di(methanol)

Base Information

Chemical Name:(-)-(4S,4'S,5S,5'S)-4,4',5,5'-Tetrahydro-2,2'-methylene-5,5'-diphenylbis-4,4'-di(methanol)
CAS No.:133463-87-3
Molecular Formula:C₂₁H₂₂N₂O₄
Molecular Weight:366.417
Hs Code.:

(-)-(4S,4'S,5S,5'S)-4,4',5,5'-Tetrahydro-2,2'-methylene-5,5'-diphenylbis<oxazole>-4,4'-di(methanol)

Synonyms:(-)-(4S,4'S,5S,5'S)-4,4',5,5'-Tetrahydro-2,2'-methylene-5,5'-diphenylbis-4,4'-di(methanol)

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Chemical Property of (-)-(4S,4'S,5S,5'S)-4,4',5,5'-Tetrahydro-2,2'-methylene-5,5'-diphenylbis-4,4'-di(methanol)

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Technology Process of (-)-(4S,4'S,5S,5'S)-4,4',5,5'-Tetrahydro-2,2'-methylene-5,5'-diphenylbis-4,4'-di(methanol)

There total 2 articles about (-)-(4S,4'S,5S,5'S)-4,4',5,5'-Tetrahydro-2,2'-methylene-5,5'-diphenylbis-4,4'-di(methanol) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 28143-91-1
(1S,2S)-2-amino-1-phenyl-1,3-diol

: 10344-69-1
diethyl malonoimidate dihydrochloride

: 133463-87-3
(-)-(4S,4'S,5S,5'S)-4,4',5,5'-Tetrahydro-2,2'-methylene-5,5'-diphenylbis-4,4'-di(methanol)

Guidance literature:: In dichloromethane; at 40 ℃; for 16h;
DOI:10.1039/a802362j

Reference yield: 52.0%

: 28143-91-1
(1S,2S)-2-amino-1-phenyl-1,3-diol

: Ethyl 3-amino-3-ethoxyprop-2-enimidate dihydrochloride

: 133463-87-3
(-)-(4S,4'S,5S,5'S)-4,4',5,5'-Tetrahydro-2,2'-methylene-5,5'-diphenylbis-4,4'-di(methanol)

Guidance literature:: In N,N-dimethyl-formamide; for 72h; Ambient temperature;
DOI:10.1002/hlca.19910740103

Reference yield: 96.0%

: 133463-87-3
(-)-(4S,4'S,5S,5'S)-4,4',5,5'-Tetrahydro-2,2'-methylene-5,5'-diphenylbis-4,4'-di(methanol)

: 124-63-0
methanesulfonyl chloride

: 430429-32-6
(-)-[(4S,5S)-4,5-dihydro-2-{[(4S,5S)-4,5-dihydro-4-{[(methylsulfonyl)oxy]methyl}-5-phenyl-1,3-oxazol-2-yl]methyl}-5-phenyl-1,3-oxazol-4-yl]methyl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h;
DOI:10.1002/1099-0690(20021)2002:2<319::AID-EJOC319>3.0.CO;2-R