1-(3-Chloro-4-methylphenyl)-4-piperidinol

Base Information

Chemical Name:1-(3-Chloro-4-methylphenyl)-4-piperidinol
CAS No.:119836-13-4
Molecular Formula:C₁₂H₁₆ClNO
Molecular Weight:225.718
Hs Code.:
DSSTox Substance ID:DTXSID801272876

Synonyms:1-(3-Chloro-4-methylphenyl)-4-piperidinol;DTXSID801272876;119836-13-4

Suppliers and Price of 1-(3-Chloro-4-methylphenyl)-4-piperidinol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(3-Chloro-4-methylphenyl)-4-piperidinol

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:225.0920418
Heavy Atom Count:15
Complexity:204

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C=C(C=C1)N2CCC(CC2)O)Cl

Technology Process of 1-(3-Chloro-4-methylphenyl)-4-piperidinol

There total 3 articles about 1-(3-Chloro-4-methylphenyl)-4-piperidinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.5%

: 115012-48-1
1-(2-fluorophenyl)-4,4-dimethoxypiperidine

: 95-74-9,827571-80-2
3-chloro-p-toluidine

: 119836-13-4
1-(3-chloro-4-tolyl)piperidin-4-ol

Guidance literature:: With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

Reference yield:

: 115012-46-9
1-(2-fluorophenyl)piperidin-4-one

: 119836-13-4
1-(3-chloro-4-tolyl)piperidin-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / toluene-4-sulphonic acid / methanol / 0.17 h / Heating

2: 64.5 percent / K₂CO₃, NaI / dimethylformamide / 2 h / 100 °C

With potassium carbonate; sodium iodide; toluene-4-sulfonic acid; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 119836-08-7
1-(2-fluorophenyl)piperidin-4-ol

: 119836-13-4
1-(3-chloro-4-tolyl)piperidin-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 67.5 percent / DCC, DMSO, pyridine, TFA / benzene / 1) 0 deg C 2) RT, 24 h

2: 75 percent / toluene-4-sulphonic acid / methanol / 0.17 h / Heating

3: 64.5 percent / K₂CO₃, NaI / dimethylformamide / 2 h / 100 °C

With pyridine; potassium carbonate; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; sodium iodide; toluene-4-sulfonic acid; In methanol; N,N-dimethyl-formamide; benzene;