115012-48-1

Upstream product

• 67-56-1 methanol 
• 348-54-9 2-Fluoroaniline 
• 3592-25-4 1,5-dichloropentan-3-one 
• 149-73-5 trimethyl orthoformate 
• 119836-08-7 1-(2-fluorophenyl)piperidin-4-ol 
• 115012-46-9 1-(2-fluorophenyl)piperidin-4-one 

Downstream Products

• 115012-46-9 1-(2-fluorophenyl)piperidin-4-one 
• 119836-13-4 1-(3-chloro-4-tolyl)piperidin-4-ol 
• 115012-52-7 1-(2-Fluorophenyl)-4-methoxy-1,2,5,6-tetrahydropyridine 

Relevant academic research and scientific papers

Facile preparation of acetals and enol ethers derived from 1-arylpiperidin-4-ones

When primary aromatic amines 6 are heated under reflux with slight excesses each of crude 1,5-dichloro-pentan-3-one 4 and toluene-4-sulfonic acid monohydrate in dry methanol solution, and an excess of trimethyl orthoformate is then added to the reactants,

A New Synthesis of 1-Arylpiperidin-4-ols

1,5-Dichloropentan-3-ol (8), which is readily prepared from the corresponding ketone (7), reacts with 2-fluoro-, 4-methyl-, 2-chloro-, 3-chloro-, 4-chloro-, and 3-chloro-4-methyl-anilines in the presence of potassium carbonate and sodium iodide in dimethy