1-{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

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Chemical Name:1-{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester
CAS No.:1396007-02-5
Molecular Formula:C₃₁H₃₁N₃O₄
Molecular Weight:509.605
Hs Code.:

Synonyms:1-{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

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Chemical Property of 1-{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

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Technology Process of 1-{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

There total 6 articles about 1-{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.6%

: 32315-10-9
bis(trichloromethyl) carbonate

: 1517-69-7
(R)-1-phenylethanol

: 1380587-87-0
1-[4'-(5-amino-1-methyl-1H-pyrazol-4-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

: 1396007-02-5
1-{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

Guidance literature:: bis(trichloromethyl) carbonate; 1-[4'-(5-amino-1-methyl-1H-pyrazol-4-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester; With triethylamine; In dichloromethane; toluene; at 90 ℃; for 0.166667h; Sealed tube;

(R)-1-phenylethanol; In dichloromethane; toluene; at 105 ℃; for 2h;

Reference yield:

: 75-44-5
phosgene

: 1517-69-7
(R)-1-phenylethanol

: 1380587-87-0
1-[4'-(5-amino-1-methyl-1H-pyrazol-4-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

: 1396007-02-5
1-{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

Guidance literature:: phosgene; 1-[4'-(5-amino-1-methyl-1H-pyrazol-4-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester; With pyridine; In dichloromethane; at 0 ℃; for 0.833333h; Molecular sieve; Inert atmosphere; Reflux;

(R)-1-phenylethanol; In dichloromethane; for 1h; Reflux;

Reference yield:

: 1215205-50-7
ethyl 1-(4-bromophenyl)cyclopropane-1-carboxylate

: 1396007-02-5
1-{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 15 h / 85 °C / Inert atmosphere; Sealed tube

2.1: triethylamine / dichloromethane / 1.5 h / 20 °C / Cooling with acetone-dry ice

3.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 90 °C / Inert atmosphere; Sealed tube

4.1: palladium diacetate; XPhos; potassium phosphate / toluene; water / 100 °C / Inert atmosphere; Sealed tube

5.1: triethylamine / toluene; dichloromethane / 0.17 h / 90 °C / Sealed tube

5.2: 2 h / 105 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; palladium diacetate; potassium carbonate; triethylamine; XPhos; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;