1215205-50-7

Basic information

• Product Name: Ethyl 1-(4-bromophenyl)cyclopropanecarboxylate
• Synonyms: Ethyl 1-(4-bromophenyl)cyclopropanecarboxylate;1-(4-Bromo-phenyl)-cyclopropanecarboxylic acid ethyl ester;ethyl1-(4-bromophenyl)cyclopropane-1-carboxylate;EOS-60373
• CAS NO: 1215205-50-7
• Molecular Formula: C₁₂H₁₃BrO₂
• Molecular Weight: 269.13442
• Mol File: 1215205-50-7.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: Room temperature.
• CAS DataBase Reference: Ethyl 1-(4-bromophenyl)cyclopropanecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 1-(4-bromophenyl)cyclopropanecarboxylate(1215205-50-7)
• EPA Substance Registry System: Ethyl 1-(4-bromophenyl)cyclopropanecarboxylate(1215205-50-7)

Safety Data

• Hazardous Substances Data: 1215205-50-7(Hazardous Substances Data)

Usage

General Description

Ethyl 1-(4-bromophenyl)cyclopropanecarboxylate is a chemical compound with the molecular formula C12H13BrO2. It is a cyclopropane derivative with an ethyl ester group and a bromine-substituted phenyl group. Ethyl 1-(4-bromophenyl)cyclopropanecarboxylate is commonly used in organic and medicinal chemistry for the synthesis of various pharmaceutical intermediates and bioactive molecules. It can also be utilized as a building block in the preparation of complex organic compounds. Its unique structure and reactivity make it a valuable component in the development of new drugs and chemical processes. However, it is important to handle this compound with caution as it may have potential hazards and health risks if not used properly.

Upstream product

• 14062-25-0 Ethyl 4-bromophenylacetate 
• 345965-52-8 1-(4-bromophenyl)cyclopropanecarboxylic acid 
• 124276-67-1 1-(4-bromophenyl)cyclopropanecarbonitrile 
• 16532-79-9 4-Bromophenylacetonitrile 
• 64-17-5 ethanol 

Downstream Products

• 1257213-50-5 (R)-1-(4'-(3-methyl-4-(((1-phenylethoxy)carbonyl)amino)isoxazol-5-yl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxylic acid 
• 1380650-63-4 1-{4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester 
• 1402465-25-1 1-(4'-{5-[1-(2-chloro-phenyl)ethoxycarbonylamino]-1-methyl-1H-pyrazol-4-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid 
• 1402466-17-4 (R)-ethyl 1-(4'-(1-methyl-5-((3-methylbutan-2-yloxy)carbonylamino)-1H-pyrazol-4-yl)biphenyl-4-yl)cyclopropanecarboxylate 
• 1380587-87-0 1-[4'-(5-amino-1-methyl-1H-pyrazol-4-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester 
• 1380587-40-5 1-[4'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1'-biphenyl]-4-yl]cyclopropane-1-carboxylic acid ethyl ester 
• 1396007-20-7 (R)-1-{4'-[5-(1,2-dimethylpropoxycarbonylamino)-1-methyl-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid 
• 1396007-17-2 (R)-1-{4'-[5-(sec-butoxycarbonylamino)-1-methyl-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid 
• 1396007-14-9 (R)-1-{4'-[1-methyl-5-((1-(3-(trifluoromethyl)-phenyl)ethoxy)-carbonylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid 
• 1396007-11-6 1-{4'-[5-((1-(4-fluorophenyl)ethoxy)carbonylamino)-1-methyl-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid 
• 1396007-08-1 (R)-1-{4'-[5-((1-(2-fluorophenyl)ethoxy)carbonylamino)-1-methyl-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid 
• 1396007-05-8 1-{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid 
• 1396007-02-5 1-{4'-[1-methyl-5-((R)-1-phenylethoxycarbonylamino)-1H-pyrazol-4-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester 
• 1402207-82-2 1-(4'-{3-Methyl-4-[6-(2-methyl-phenyl)-pyridin-2-ylamino]-isoxazol-5-yl}-biphenyl-4-yl)-cyclopropanecarboxylic acid ethyl ester 

Relevant articles and documents

Efficient cyclopropanation of aryl/heteroaryl acetates and acetonitriles with vinyl diphenyl sulfonium triflate

A convenient method was developed for the cyclopropanation of aryl acetates and aryl acetonitrile using vinyl diphenyl sulfonium triflate salt. The newly developed conditions are simple, mild, and compatible with a wide range of functional groups, without the need to apply an inert atmosphere, or alkali bases.

Development of a Concise Multikilogram Synthesis of LPA-1 Antagonist BMS-986020 via a Tandem Borylation-Suzuki Procedure

The process development for the synthesis of BMS-986020 (1) via a palladium catalyzed tandem borylation/Suzuki reaction is described. Evaluation of conditions culminated in an efficient borylation procedure using tetrahydroxydiboron followed by a tandem Suzuki reaction employing the same commercially available palladium catalyst for both steps. This methodology addressed shortcomings of early synthetic routes and was ultimately used for the multikilogram scale synthesis of the active pharmaceutical ingredient 1. Further evaluation of the borylation reaction showed useful reactivity with a range of substituted aryl bromides and iodides as coupling partners. These findings represent a practical, efficient, mild, and scalable method for borylation.

POLYCYCLIC LPA1 ANTAGONIST AND USES THEREOF

Described herein is the LPA1 antagonist 1- {4'-[3-methyl-4-((R)- l-phenyl-ethoxycarbonylamino)- isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid (Compound 1), or pharmaceutically acceptable salts thereof. Also described are methods of preparing t