4-FLUORO-3-NITROPHENYL AZIDE

Base Information

• Chemical Name: 4-FLUORO-3-NITROPHENYL AZIDE
• CAS No.: 67312-96-3
• Molecular Formula: C6H3 F N4 O2
• Molecular Weight: 182.114
• Mol file: 67312-96-3.mol

Synonyms:4-Fluoro-2-nitrophenylazide

Chemical Property of 4-FLUORO-3-NITROPHENYL AZIDE

Chemical Property:

• PSA: 95.57000
• LogP: 2.65166

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-FLUORO-3-NITROPHENYL AZIDE

There total 4 articles about 4-FLUORO-3-NITROPHENYL AZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-nitro-4-fluoroaniline (364-78-3) → 1-azido-4-fluoro-2-nitrobenzene (67312-96-3)

Guidance literature:

With sodium azide; trifluoroacetic acid; sodium nitrite; sulfuric acid; at 15 ℃;

DOI:10.1016/S0022-1139(03)00011-3

Reference yield:

4'-fluoroacetanilide (351-83-7) → 1-azido-4-fluoro-2-nitrobenzene (67312-96-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / HNO₃ / acetic acid / 4 h / 90 °C

2: 85 percent / CF₃CO₂H; NaNO₂; aq. NaN₃ / H₂SO₄ / 15 °C

With sodium azide; nitric acid; trifluoroacetic acid; sodium nitrite; sulfuric acid; In acetic acid;

DOI:10.1016/S0022-1139(03)00011-3

Reference yield:

4-fluoroaniline (371-40-4) → 1-azido-4-fluoro-2-nitrobenzene (67312-96-3)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. HCl / 90 °C

2: 54 percent / HNO₃ / acetic acid / 4 h / 90 °C

3: 85 percent / CF₃CO₂H; NaNO₂; aq. NaN₃ / H₂SO₄ / 15 °C

With hydrogenchloride; sodium azide; nitric acid; trifluoroacetic acid; sodium nitrite; sulfuric acid; In acetic acid;

DOI:10.1016/S0022-1139(03)00011-3

upstream raw materials:

2-nitro-4-fluoroaniline

4'-fluoroacetanilide

4-fluoroaniline

N-(4-fluoro-2-nitrophenyl)acetamide

Downstream raw materials:

5-Fluorobenzofuroxan

5-fluoro-2,1,3-benzoxadiazole N³-oxide

5-(2-amino-4-fluoro-phenylamino)-1H-[1,2,3]triazole-4-carboxylic acid amide

5-(4-fluoro-2-nitro-phenylamino)-1H-[1,2,3]triazole-4-carboxylic acid amide