N-(5-{[2-(cyclopropanecarboxamido)imidazo[1,2-b]pyridazin-6-yl]oxy}-2-fluorophenyl)-1-ethyl-3-methyl-1H-pyrazole-4-carboxamide

Base Information

Chemical Name:N-(5-{[2-(cyclopropanecarboxamido)imidazo[1,2-b]pyridazin-6-yl]oxy}-2-fluorophenyl)-1-ethyl-3-methyl-1H-pyrazole-4-carboxamide
CAS No.:1005782-08-0
Molecular Formula:C₂₃H₂₂FN₇O₃
Molecular Weight:463.471
Hs Code.:

Synonyms:N-(5-{[2-(cyclopropanecarboxamido)imidazo[1,2-b]pyridazin-6-yl]oxy}-2-fluorophenyl)-1-ethyl-3-methyl-1H-pyrazole-4-carboxamide

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Chemical Property of N-(5-{[2-(cyclopropanecarboxamido)imidazo[1,2-b]pyridazin-6-yl]oxy}-2-fluorophenyl)-1-ethyl-3-methyl-1H-pyrazole-4-carboxamide

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Technology Process of N-(5-{[2-(cyclopropanecarboxamido)imidazo[1,2-b]pyridazin-6-yl]oxy}-2-fluorophenyl)-1-ethyl-3-methyl-1H-pyrazole-4-carboxamide

There total 6 articles about N-(5-{[2-(cyclopropanecarboxamido)imidazo[1,2-b]pyridazin-6-yl]oxy}-2-fluorophenyl)-1-ethyl-3-methyl-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1175127-29-3
N-(6-chloroimidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide

: 1451192-49-6
1-ethyl-N-(2-fluoro-5-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carboxamide

: 1005782-08-0
N-(5-{[2-(cyclopropanecarboxamido)imidazo[1,2-b]pyridazin-6-yl]oxy}-2-fluorophenyl)-1-ethyl-3-methyl-1H-pyrazole-4-carboxamide

Guidance literature:: With caesium carbonate; In dimethyl sulfoxide; at 100 - 110 ℃; for 4h;
DOI:10.1016/j.tet.2013.07.087

Reference yield: 52.0%

: 79-37-8
oxalyl dichloride

: 113131-46-7
1-ethyl-3-methyl-1H-pyrazole-4-carboxylic acid

: 1005781-39-4
N-[6-(3-amino-4-fluorophenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide

: 1005782-08-0
N-(5-{[2-(cyclopropanecarboxamido)imidazo[1,2-b]pyridazin-6-yl]oxy}-2-fluorophenyl)-1-ethyl-3-methyl-1H-pyrazole-4-carboxamide

Guidance literature:: In tetrahydrofuran; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

: 1175127-57-7
N-(2-chloroacetyl)cyclopropanecarboxamide

: 1005782-08-0
N-(5-{[2-(cyclopropanecarboxamido)imidazo[1,2-b]pyridazin-6-yl]oxy}-2-fluorophenyl)-1-ethyl-3-methyl-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: disodium hydrogenphosphate / N,N-dimethyl acetamide / 4 h / 100 °C

2: caesium carbonate / dimethyl sulfoxide / 4 h / 100 - 110 °C

With disodium hydrogenphosphate; caesium carbonate; In N,N-dimethyl acetamide; dimethyl sulfoxide;
DOI:10.1016/j.tet.2013.07.087