(1S,2R)-(-)-3-<2'-(tert-butyldimethylsilyloxy)ethyl>-2,2-dimethyl-4-methylene-1-cyclohexanol

Base Information

Chemical Name:(1S,2R)-(-)-3-<2'-(tert-butyldimethylsilyloxy)ethyl>-2,2-dimethyl-4-methylene-1-cyclohexanol
CAS No.:124462-83-5
Molecular Formula:C₁₇H₃₄O₂Si
Molecular Weight:298.541
Hs Code.:

Synonyms:(1S,2R)-(-)-3-<2'-(tert-butyldimethylsilyloxy)ethyl>-2,2-dimethyl-4-methylene-1-cyclohexanol

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Chemical Property of (1S,2R)-(-)-3-<2'-(tert-butyldimethylsilyloxy)ethyl>-2,2-dimethyl-4-methylene-1-cyclohexanol

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Technology Process of (1S,2R)-(-)-3-<2'-(tert-butyldimethylsilyloxy)ethyl>-2,2-dimethyl-4-methylene-1-cyclohexanol

There total 2 articles about (1S,2R)-(-)-3-<2'-(tert-butyldimethylsilyloxy)ethyl>-2,2-dimethyl-4-methylene-1-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 124462-82-4
(1R,3S)-2-(-)-3-hydroxy-2,2-dimethyl-6-methylene-1-cyclohexaneethanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 124462-83-5
(1S,2R)-(-)-3-<2'-(tert-butyldimethylsilyloxy)ethyl>-2,2-dimethyl-4-methylene-1-cyclohexanol

Guidance literature:: With triethylamine; In dichloromethane; for 20h; Ambient temperature;

Reference yield:

: 124177-09-9
ethyl (1R,3S)-3-hydroxy-2,2-dimethyl-6-methylenecyclohexaneacetate

: 124462-83-5
(1S,2R)-(-)-3-<2'-(tert-butyldimethylsilyloxy)ethyl>-2,2-dimethyl-4-methylene-1-cyclohexanol

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / LiAlH₄ / CH₂Cl₂ / 20 h / Ambient temperature

2: 98 percent / NEt₃ / CH₂Cl₂ / 20 h / Ambient temperature

With lithium aluminium tetrahydride; triethylamine; In dichloromethane;

Reference yield:

: 124462-83-5
(1S,2R)-(-)-3-<2'-(tert-butyldimethylsilyloxy)ethyl>-2,2-dimethyl-4-methylene-1-cyclohexanol

: 473-03-0
(1R,4aα)-1-[(E)-6-[(S)-2,2-dimethyl-6-methylenecyclohexyl]-4-methyl-3-hexenyl]decahydro-2,5,5,8aβ-tetramethylnaphthalene-2α-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 1. n-butyllithium, N,N,N',N'-tetramethylethylendiamine / 1. n-hexane, 1,2-dimethoxyethane, 2 h, room temperature 2. 20 h, room temperature

3: 78 percent / K₂CO₃ / methanol / 12 h / Ambient temperature

5: 81 percent / pyridine, 4-(dimethylamino)pyridine / 12 h / Ambient temperature

6: 1. Li, t-BuOH 2. dil. HCl, 80percent aq. AcOH / 1. ethylamine, -78 deg C, 10 min 2. room temperature

With pyridine; hydrogenchloride; dmap; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; lithium; potassium carbonate; acetic acid; tert-butyl alcohol; In methanol;