(4-(3-(aminomethyl)phenyl)piperidin-1-yl)(6-(hydroxydimethylsilyl)-1-methyl-1H-indol-3-yl)methanone

Base Information

Chemical Name:(4-(3-(aminomethyl)phenyl)piperidin-1-yl)(6-(hydroxydimethylsilyl)-1-methyl-1H-indol-3-yl)methanone
CAS No.:1431289-35-8
Molecular Formula:C₂₄H₃₁N₃O₂Si
Molecular Weight:421.615
Hs Code.:

Synonyms:(4-(3-(aminomethyl)phenyl)piperidin-1-yl)(6-(hydroxydimethylsilyl)-1-methyl-1H-indol-3-yl)methanone

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Chemical Property of (4-(3-(aminomethyl)phenyl)piperidin-1-yl)(6-(hydroxydimethylsilyl)-1-methyl-1H-indol-3-yl)methanone

Chemical Property:

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Technology Process of (4-(3-(aminomethyl)phenyl)piperidin-1-yl)(6-(hydroxydimethylsilyl)-1-methyl-1H-indol-3-yl)methanone

There total 5 articles about (4-(3-(aminomethyl)phenyl)piperidin-1-yl)(6-(hydroxydimethylsilyl)-1-methyl-1H-indol-3-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431289-24-5
tert-butyl 3-(1-(6-(hydroxydimethylsilyl)-1-methyl-1H-indole-3-carbonyl)piperidin-4-yl)benzylcarbamate

: 1431289-35-8
(4-(3-(aminomethyl)phenyl)piperidin-1-yl)(6-(hydroxydimethylsilyl)-1-methyl-1H-indol-3-yl)methanone

Guidance literature:: With phosphoric acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 725228-49-9
tert-butyl 3-(piperidin-4-yl)benzylcarbamate

: 1431289-35-8
(4-(3-(aminomethyl)phenyl)piperidin-1-yl)(6-(hydroxydimethylsilyl)-1-methyl-1H-indol-3-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 15 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: johnphos; palladium dichloride; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 10 h / 60 °C

3.2: 2 h / 20 °C

4.1: phosphoric acid / dichloromethane / 1 h / 20 °C

With phosphoric acid; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium dichloride; johnphos; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 101774-27-0
6-bromo-1H-indole-3-carboxylic acid

: 1431289-35-8
(4-(3-(aminomethyl)phenyl)piperidin-1-yl)(6-(hydroxydimethylsilyl)-1-methyl-1H-indol-3-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 15 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: johnphos; palladium dichloride; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 10 h / 60 °C

3.2: 2 h / 20 °C

4.1: phosphoric acid / dichloromethane / 1 h / 20 °C

With phosphoric acid; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium dichloride; johnphos; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide;