tert-butyl 3-(1-(6-bromo-1-methyl-1H-indole-3-carbonyl)piperidin-4-yl)benzylcarbamate

Base Information

Chemical Name:tert-butyl 3-(1-(6-bromo-1-methyl-1H-indole-3-carbonyl)piperidin-4-yl)benzylcarbamate
CAS No.:1431289-15-4
Molecular Formula:C₂₇H₃₂BrN₃O₃
Molecular Weight:526.473
Hs Code.:

Synonyms:tert-butyl 3-(1-(6-bromo-1-methyl-1H-indole-3-carbonyl)piperidin-4-yl)benzylcarbamate

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Chemical Property of tert-butyl 3-(1-(6-bromo-1-methyl-1H-indole-3-carbonyl)piperidin-4-yl)benzylcarbamate

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Technology Process of tert-butyl 3-(1-(6-bromo-1-methyl-1H-indole-3-carbonyl)piperidin-4-yl)benzylcarbamate

There total 3 articles about tert-butyl 3-(1-(6-bromo-1-methyl-1H-indole-3-carbonyl)piperidin-4-yl)benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1431289-14-3
tert-butyl 3-(1-(6-bromo-1H-indole-3-carbonyl)piperidin-4-yl)benzylcarbamate

: 74-88-4
methyl iodide

: 1431289-15-4
tert-butyl 3-(1-(6-bromo-1-methyl-1H-indole-3-carbonyl)piperidin-4-yl)benzylcarbamate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 101774-27-0
6-bromo-1H-indole-3-carboxylic acid

: 1431289-15-4
tert-butyl 3-(1-(6-bromo-1-methyl-1H-indole-3-carbonyl)piperidin-4-yl)benzylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 15 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

With potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

Reference yield:

: 725228-49-9
tert-butyl 3-(piperidin-4-yl)benzylcarbamate

: 1431289-15-4
tert-butyl 3-(1-(6-bromo-1-methyl-1H-indole-3-carbonyl)piperidin-4-yl)benzylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 15 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

With potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;