tert-butyl 3-(1-(6-bromo-1H-indole-3-carbonyl)piperidin-4-yl)benzylcarbamate

Base Information

Chemical Name:tert-butyl 3-(1-(6-bromo-1H-indole-3-carbonyl)piperidin-4-yl)benzylcarbamate
CAS No.:1431289-14-3
Molecular Formula:C₂₆H₃₀BrN₃O₃
Molecular Weight:512.447
Hs Code.:

Synonyms:tert-butyl 3-(1-(6-bromo-1H-indole-3-carbonyl)piperidin-4-yl)benzylcarbamate

Suppliers and Price of tert-butyl 3-(1-(6-bromo-1H-indole-3-carbonyl)piperidin-4-yl)benzylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of tert-butyl 3-(1-(6-bromo-1H-indole-3-carbonyl)piperidin-4-yl)benzylcarbamate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl 3-(1-(6-bromo-1H-indole-3-carbonyl)piperidin-4-yl)benzylcarbamate

There total 1 articles about tert-butyl 3-(1-(6-bromo-1H-indole-3-carbonyl)piperidin-4-yl)benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 101774-27-0
6-bromo-1H-indole-3-carboxylic acid

: 725228-49-9
tert-butyl 3-(piperidin-4-yl)benzylcarbamate

: 1431289-14-3
tert-butyl 3-(1-(6-bromo-1H-indole-3-carbonyl)piperidin-4-yl)benzylcarbamate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 15h;

Reference yield: 97.0%

: 1431289-14-3
tert-butyl 3-(1-(6-bromo-1H-indole-3-carbonyl)piperidin-4-yl)benzylcarbamate

: 74-88-4
methyl iodide

: 1431289-15-4
tert-butyl 3-(1-(6-bromo-1-methyl-1H-indole-3-carbonyl)piperidin-4-yl)benzylcarbamate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 1431289-14-3
tert-butyl 3-(1-(6-bromo-1H-indole-3-carbonyl)piperidin-4-yl)benzylcarbamate

: 1431289-24-5
tert-butyl 3-(1-(6-(hydroxydimethylsilyl)-1-methyl-1H-indole-3-carbonyl)piperidin-4-yl)benzylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: johnphos; palladium dichloride; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 10 h / 60 °C

2.2: 2 h / 20 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium dichloride; johnphos; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;