(1R,2R)-N,N′-dimethyl-N,N′-di[(2-hydroxy-3,5-di(tert-butyl))benzyl]-1,2-diaminocyclohexane

Base Information

• Chemical Name: (1R,2R)-N,N′-dimethyl-N,N′-di[(2-hydroxy-3,5-di(tert-butyl))benzyl]-1,2-diaminocyclohexane
• CAS No.: 914614-75-8
• Molecular Formula: C₃₈H₆₂N₂O₂
• Molecular Weight: 578.922
• Mol file: 914614-75-8.mol

Synonyms:(1R,2R)-N,N′-dimethyl-N,N′-di[(2-hydroxy-3,5-di(tert-butyl))benzyl]-1,2-diaminocyclohexane

Chemical Property of (1R,2R)-N,N′-dimethyl-N,N′-di[(2-hydroxy-3,5-di(tert-butyl))benzyl]-1,2-diaminocyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R)-N,N′-dimethyl-N,N′-di[(2-hydroxy-3,5-di(tert-butyl))benzyl]-1,2-diaminocyclohexane

There total 1 articles about (1R,2R)-N,N′-dimethyl-N,N′-di[(2-hydroxy-3,5-di(tert-butyl))benzyl]-1,2-diaminocyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 6,6′-({[(1R,2R)-cyclohexane-1,2-diyl]bis(azanediyl)}bis-[methylene])bis(2,4-di-tert-butylphenol) (812693-91-7) → (1R,2R)-N,N′-dimethyl-N,N′-di[(2-hydroxy-3,5-di(tert-butyl))benzyl]-1,2-diaminocyclohexane (914614-75-8)

Guidance literature:

formaldehyd; 6,6′-({[(1R,2R)-cyclohexane-1,2-diyl]bis(azanediyl)}bis-[methylene])bis(2,4-di-tert-butylphenol); In water; acetic acid; acetonitrile; at 20 ℃; for 0.333333h;

With sodium tetrahydroborate; In water; acetic acid; acetonitrile;

DOI:10.1016/j.tet.2021.132085

Reference yield: 73.0%

(1R,2R)-N,N′-dimethyl-N,N′-di[(2-hydroxy-3,5-di(tert-butyl))benzyl]-1,2-diaminocyclohexane (914614-75-8) + methyl iodide (74-88-4) → 2,4-di(tert-butyl)-6-((((1R,2R)-2-((3,5-di(tert-butyl)-2-methoxybenzyl)(methyl)amino)cyclohexyl)(methyl)amino)methyl)phenol

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.tet.2021.132085

Reference yield:

(1R,2R)-N,N′-dimethyl-N,N′-di[(2-hydroxy-3,5-di(tert-butyl))benzyl]-1,2-diaminocyclohexane (914614-75-8) + tetrabenzylzirconium(IV) (24356-01-2) → (R,R)-Δ-(OC6H2(tert-butyl)2CH2N(Me)C6H10N(Me)CH2C6H2(tert-butyl)2O)dibenzylzirconium

Guidance literature:

In toluene; byproducts: toluene; ligand reacted with Zn compd. in toluene at room temp. for 2 h; detd. by (1)H NMR spectra;

DOI:10.1021/ja0647654

upstream raw materials:

formaldehyd

6,6′-({[(1R,2R)-cyclohexane-1,2-diyl]bis(azanediyl)}bis-[methylene])bis(2,4-di-tert-butylphenol)