5-<3,5-dimethyl-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>phenyl>-2H-tetrazole

Base Information

• Chemical Name: 5-<3,5-dimethyl-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>phenyl>-2H-tetrazole
• CAS No.: 152775-44-5
• Molecular Formula: C₁₆H₁₉N₅O₂
• Molecular Weight: 313.359
• Mol file: 152775-44-5.mol

Synonyms:5-<3,5-dimethyl-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>phenyl>-2H-tetrazole

Chemical Property of 5-<3,5-dimethyl-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>phenyl>-2H-tetrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-<3,5-dimethyl-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>phenyl>-2H-tetrazole

There total 3 articles about 5-<3,5-dimethyl-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>phenyl>-2H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3,5-dimethyl-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>benzonitrile (130226-18-5) → 5-<3,5-dimethyl-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>phenyl>-2H-tetrazole (152775-44-5)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; sodium azide; tetraethylammonium chloride; at 150 ℃; for 5h;

DOI:10.1021/jm00074a004

Reference yield:

3,5-dimethyl-4-hydroxybenzonitrile (4198-90-7) → 5-<3,5-dimethyl-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>phenyl>-2H-tetrazole (152775-44-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 94.1 percent / K₂CO₃, KI, N-methylpyrrolidinone / 18 h / 60 °C

2: 89 percent / NaN₃, tetraethylamine hydrochloride, N-methylpyrrolidinone / 5 h / 150 °C

With 1-methyl-pyrrolidin-2-one; sodium azide; tetraethylammonium chloride; potassium carbonate; potassium iodide;

DOI:10.1021/jm00074a004

Reference yield:

3-(3-methylisoxazol-5-yl)propyl chloride (130800-76-9) → 5-<3,5-dimethyl-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>phenyl>-2H-tetrazole (152775-44-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 94.1 percent / K₂CO₃, KI, N-methylpyrrolidinone / 18 h / 60 °C

2: 89 percent / NaN₃, tetraethylamine hydrochloride, N-methylpyrrolidinone / 5 h / 150 °C

With 1-methyl-pyrrolidin-2-one; sodium azide; tetraethylammonium chloride; potassium carbonate; potassium iodide;

DOI:10.1021/jm00074a004

upstream raw materials:

3,5-dimethyl-4-<<3-(3-methyl-5-isoxazolyl)propyl>oxy>benzonitrile

3,5-dimethyl-4-hydroxybenzonitrile

3-(3-methylisoxazol-5-yl)propyl chloride