(RS,SR)-5,6-bis<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2,8-decadiynedioic acid dimethyl ester

Base Information

Chemical Name:(RS,SR)-5,6-bis<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2,8-decadiynedioic acid dimethyl ester
CAS No.:116503-84-5
Molecular Formula:C₄₆H₅₄O₆Si₂
Molecular Weight:759.102
Hs Code.:

Synonyms:(RS,SR)-5,6-bis<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2,8-decadiynedioic acid dimethyl ester

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Chemical Property of (RS,SR)-5,6-bis<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2,8-decadiynedioic acid dimethyl ester

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Technology Process of (RS,SR)-5,6-bis<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2,8-decadiynedioic acid dimethyl ester

There total 4 articles about (RS,SR)-5,6-bis<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2,8-decadiynedioic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 116503-83-4
(RS,SR)-4,5-bis<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-1,1,8,8-tetrabromo-1,7-octadiene

: 79-22-1
methyl chloroformate

: 116503-84-5
(RS,SR)-5,6-bis<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2,8-decadiynedioic acid dimethyl ester

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 - 0 ℃; for 1.25h;
DOI:10.1021/ja00229a068

Reference yield:

: 116503-81-2
(RS,SR)-1,2-bis[{[(1,1-dimethylethyl)diphenylsilyl]oxy}methyl]-4-cyclohexene

: 116503-84-5
(RS,SR)-5,6-bis<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2,8-decadiynedioic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) O₃, 2.) (MeO)3P / 1.) EtOAc-MeOH 1:1, -78 deg C, 2.) from -78 deg C to 25 deg C, 10 h

2: PPh₃ / CH₂Cl₂ / 8 h / 0 - 25 °C

3: 74 percent / n-BuLi / tetrahydrofuran / 1.25 h / -78 - 0 °C

With n-butyllithium; ozone; triphenylphosphine; phosphorous acid trimethyl ester; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00229a068

Reference yield:

: 116503-82-3
(3R,4S)-3,4-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-hexanedial

: 116503-84-5
(RS,SR)-5,6-bis<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2,8-decadiynedioic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: PPh₃ / CH₂Cl₂ / 8 h / 0 - 25 °C

2: 74 percent / n-BuLi / tetrahydrofuran / 1.25 h / -78 - 0 °C

With n-butyllithium; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00229a068