N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)nicotinamide

Base Information

Chemical Name:N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)nicotinamide
CAS No.:1024592-65-1
Molecular Formula:C₂₅H₂₇N₃O₃
Molecular Weight:417.508
Hs Code.:
Mol file:1024592-65-1.mol

Synonyms:N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)nicotinamide

Suppliers and Price of N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)nicotinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)nicotinamide

Chemical Property:

Purity/Quality:

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Technology Process of N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)nicotinamide

There total 5 articles about N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 10400-19-8
3-pyridinecarbonyl chloride

: 82925-02-8
4-<2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolyl)ethyl>benzenamine

: 1024592-65-1
N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)nicotinamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 48h;
DOI:10.1016/j.bmc.2009.01.072

Reference yield:

: 5339-26-4
(4-nitrophenyl)ethyl bromide

: 1024592-65-1
N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / Inert atmosphere

2: palladium on activated charcoal; hydrogen / ethanol

3: acetonitrile / 24 h / 20 °C

With palladium on activated charcoal; hydrogen; potassium carbonate; In ethanol; acetonitrile;
DOI:10.1080/14756366.2020.1747449

Reference yield:

: 2328-12-3
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline monohydrochloride

: 1024592-65-1
N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / Inert atmosphere

2: palladium on activated charcoal; hydrogen / ethanol

3: acetonitrile / 24 h / 20 °C

With palladium on activated charcoal; hydrogen; potassium carbonate; In ethanol; acetonitrile;
DOI:10.1080/14756366.2020.1747449