2,2-Dimethyl-propionic acid (S)-4-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-butyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (S)-4-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-butyl ester
CAS No.:177905-27-0
Molecular Formula:C₂₅H₃₆O₄Si
Molecular Weight:428.644
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid (S)-4-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-butyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (S)-4-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-butyl ester

Chemical Property:

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Technology Process of 2,2-Dimethyl-propionic acid (S)-4-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-butyl ester

There total 3 articles about 2,2-Dimethyl-propionic acid (S)-4-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 116996-52-2
(2S)-4-O-(tert-butyldiphenylsilyl)butane-1,2,4-triol

: 3282-30-2
pivaloyl chloride

: 177905-27-0
2,2-Dimethyl-propionic acid (S)-4-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-butyl ester

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1016/0040-4039(96)00563-1

Reference yield:

: 146028-83-3
(2S)-1,2-O-isopropylidene-4-(tert-butyldiphenylsilyl)butane-1,2,4-triol

: 177905-27-0
2,2-Dimethyl-propionic acid (S)-4-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / HS(CH₂)2SH, pTSA / CHCl₃ / Heating

2: 93 percent / Et₃N / CH₂Cl₂

With toluene-4-sulfonic acid; ethane-1,2-dithiol; triethylamine; In dichloromethane; chloroform;
DOI:10.1016/0040-4039(96)00563-1

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 177905-27-0
2,2-Dimethyl-propionic acid (S)-4-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / Et₃N, DMAP / CH₂Cl₂

2: 60 percent / HS(CH₂)2SH, pTSA / CHCl₃ / Heating

3: 93 percent / Et₃N / CH₂Cl₂

With dmap; toluene-4-sulfonic acid; ethane-1,2-dithiol; triethylamine; In dichloromethane; chloroform;
DOI:10.1016/0040-4039(96)00563-1