(1S,2'S,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-4,4a,4b,5,6,7,8,8a,9,9a-decahydrospiro(1H-4b,9-etheno-4H-fluorene-4,2'-4'-methyl-isoxazoline)-1-ol

Base Information

Chemical Name:(1S,2'S,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-4,4a,4b,5,6,7,8,8a,9,9a-decahydrospiro(1H-4b,9-etheno-4H-fluorene-4,2'-4'-methyl-isoxazoline)-1-ol
CAS No.:210887-64-2
Molecular Formula:C₂₆H₃₁NO₃
Molecular Weight:405.537
Hs Code.:

(1S,2'S,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-4,4a,4b,5,6,7,8,8a,9,9a-decahydrospiro(1H-4b,9-etheno-4H-fluorene-4,2'-4'-methyl-isoxazoline)-1-ol

Synonyms:(1S,2'S,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-4,4a,4b,5,6,7,8,8a,9,9a-decahydrospiro(1H-4b,9-etheno-4H-fluorene-4,2'-4'-methyl-isoxazoline)-1-ol

Suppliers and Price of (1S,2'S,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-4,4a,4b,5,6,7,8,8a,9,9a-decahydrospiro(1H-4b,9-etheno-4H-fluorene-4,2'-4'-methyl-isoxazoline)-1-ol

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Chemical Property of (1S,2'S,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-4,4a,4b,5,6,7,8,8a,9,9a-decahydrospiro(1H-4b,9-etheno-4H-fluorene-4,2'-4'-methyl-isoxazoline)-1-ol

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Technology Process of (1S,2'S,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-4,4a,4b,5,6,7,8,8a,9,9a-decahydrospiro(1H-4b,9-etheno-4H-fluorene-4,2'-4'-methyl-isoxazoline)-1-ol

There total 5 articles about (1S,2'S,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-4,4a,4b,5,6,7,8,8a,9,9a-decahydrospiro(1H-4b,9-etheno-4H-fluorene-4,2'-4'-methyl-isoxazoline)-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 210887-48-2
(2'S,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-4,4a,4b,5,6,7,8,8a,9,9a-decahydrospiro(1H-4b,9-etheno-4H-fluorene-4,2'-4'-methyl-isoxazoline)-1-one

: 210887-64-2
(1S,2'S,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-4,4a,4b,5,6,7,8,8a,9,9a-decahydrospiro(1H-4b,9-etheno-4H-fluorene-4,2'-4'-methyl-isoxazoline)-1-ol

Guidance literature:: With sodium tetrahydroborate; cerium(III) chloride; In methanol; dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1016/S0040-4020(98)00158-6

Reference yield:

: 160695-09-0
(S)-3-(4-Methoxy-phenyl)-3a-methyl-4,5,6,7-tetrahydro-3aH-indene

: 210887-64-2
(1S,2'S,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-4,4a,4b,5,6,7,8,8a,9,9a-decahydrospiro(1H-4b,9-etheno-4H-fluorene-4,2'-4'-methyl-isoxazoline)-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / CH₂Cl₂ / 504 h / 4875390 Torr

2: 78 percent / CeCl₃*7H₂O, NaBH₄ / CH₂Cl₂; methanol / 0.5 h / 0 °C

With sodium tetrahydroborate; cerium(III) chloride; In methanol; dichloromethane;
DOI:10.1016/S0040-4020(98)00158-6

Reference yield:

: 210887-73-3
(2'S,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-4,4a,4b,5,6,7,8,8a,9,9a-decahydrospiro(1H-4b,9-etheno-4H-fluorene-4,2'-4'-carboxylic acid methyl ester-isoxazoline)-1-one

: 210887-64-2
(1S,2'S,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-4,4a,4b,5,6,7,8,8a,9,9a-decahydrospiro(1H-4b,9-etheno-4H-fluorene-4,2'-4'-methyl-isoxazoline)-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / RuCl₃*xH₂O, NaIO₄ / ethyl acetate; acetonitrile; H₂O / 0.08 h / 0 °C

2: 90 percent / p-TsOH / acetonitrile / 12 h / Heating

3: 2 h / 300 °C / 2*10^-2 mbar

4: 88 percent / CH₂Cl₂ / 504 h / 4875390 Torr

5: 78 percent / CeCl₃*7H₂O, NaBH₄ / CH₂Cl₂; methanol / 0.5 h / 0 °C

With ruthenium trichloride; sodium tetrahydroborate; sodium periodate; cerium(III) chloride; toluene-4-sulfonic acid; In methanol; dichloromethane; water; ethyl acetate; acetonitrile;
DOI:10.1016/S0040-4020(98)00158-6