(R)-3-(5-bromo-2-fluoro-phenyl)-4-(4-methoxy-benzyl)-3-methyl-[1,4]oxazepan-5-one

Base Information

Chemical Name:(R)-3-(5-bromo-2-fluoro-phenyl)-4-(4-methoxy-benzyl)-3-methyl-[1,4]oxazepan-5-one
CAS No.:1346146-74-4
Molecular Formula:C₂₀H₂₁BrFNO₃
Molecular Weight:422.294
Hs Code.:

Synonyms:(R)-3-(5-bromo-2-fluoro-phenyl)-4-(4-methoxy-benzyl)-3-methyl-[1,4]oxazepan-5-one

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Chemical Property of (R)-3-(5-bromo-2-fluoro-phenyl)-4-(4-methoxy-benzyl)-3-methyl-[1,4]oxazepan-5-one

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Technology Process of (R)-3-(5-bromo-2-fluoro-phenyl)-4-(4-methoxy-benzyl)-3-methyl-[1,4]oxazepan-5-one

There total 9 articles about (R)-3-(5-bromo-2-fluoro-phenyl)-4-(4-methoxy-benzyl)-3-methyl-[1,4]oxazepan-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1346146-73-3
N-[(R)-1-(5-bromo-2-fluoro-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-3-chloro-N-(4-methoxy-benzyl)-propionamide

: 1346146-74-4
(R)-3-(5-bromo-2-fluoro-phenyl)-4-(4-methoxy-benzyl)-3-methyl-[1,4]oxazepan-5-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

Reference yield:

: 1262859-53-9
4-bromo-1-fluoro-2-isopropenyl-benzene

: 1346146-74-4
(R)-3-(5-bromo-2-fluoro-phenyl)-4-(4-methoxy-benzyl)-3-methyl-[1,4]oxazepan-5-one

Guidance literature:: Multi-step reaction with 8 steps

1: iodine / ethyl acetate; acetonitrile / 16.75 h / 0 - 20 °C / Inert atmosphere; Darkness

2: silver tetrafluoroborate / N,N-dimethyl-formamide; tert-butyl alcohol / 16 h / 80 °C

3: Chiralpak AD / n-heptane; ethanol

4: lithium hydroxide monohydrate / ethanol; water / 100 °C

5: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 0.5 h / 20 °C

6: dmap; triethylamine / dichloromethane / 16 h / 20 °C

7: sodium hydrogencarbonate / chloroform / 16 h / 0 - 20 °C

8: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 - 20 °C

With dmap; silver tetrafluoroborate; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; iodine; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; ethanol; n-heptane; dichloromethane; chloroform; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

Reference yield:

: 1266785-96-9
(R)-2-(5-bromo-2-fluoro-phenyl)-2-(4-methoxy-benzylamino)-propan-1-ol

: 1346146-74-4
(R)-3-(5-bromo-2-fluoro-phenyl)-4-(4-methoxy-benzyl)-3-methyl-[1,4]oxazepan-5-one

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; triethylamine / dichloromethane / 16 h / 20 °C

2: sodium hydrogencarbonate / chloroform / 16 h / 0 - 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 - 20 °C

With dmap; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; dichloromethane; chloroform;