6-phenoxyquinoline

Base Information

• Chemical Name: 6-phenoxyquinoline
• CAS No.: 855761-16-9
• Molecular Formula: C₁₅H₁₁NO
• Molecular Weight: 221.258
• Mol file: 855761-16-9.mol

Synonyms:6-phenoxyquinoline

Chemical Property of 6-phenoxyquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-phenoxyquinoline

There total 5 articles about 6-phenoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

6-bromoquinoline (5332-25-2) + phenol (108-95-2,27073-41-2) → 6-phenoxyquinoline (855761-16-9)

Guidance literature:

With potassium phosphate; copper(l) iodide; N,N’-bis(2-phenylphenyl)oxalic acid; In N,N-dimethyl-formamide; at 90 ℃; for 24h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.7b00493

Reference yield: 93.0%

6-chloroquinoline (612-57-7) + phenol (108-95-2,27073-41-2) → 6-phenoxyquinoline (855761-16-9)

Guidance literature:

With potassium phosphate; copper(l) iodide; N¹-benzyl-N²-(5-methyl-[1,1'-biphenyl]-2-yl)oxalamide; In N,N-dimethyl-formamide; at 120 ℃; for 24h; Inert atmosphere;

DOI:10.1002/anie.201601035

Reference yield:

(E)-4-phenoxy-N-((E)-3-phenylallylidene)aniline → 6-phenoxyquinoline (855761-16-9)

Guidance literature:

With trifluorormethanesulfonic acid; at 80 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1016/j.tetlet.2020.151630

upstream raw materials:

glycerol

4-phenoxyanilin

6-bromoquinoline

phenol

Downstream raw materials:

6-phenoxy-8-phenylquinoline

Refernces

• 1、 Klumpp, Douglas A.,Stentzel, Michael R.,Vuong, Hein. "Superacid-promoted synthesis of quinoline derivatives". . . Retrieved 2020/01/24.
• 2、 Fan, Mengyang,Zhou, Wei,Jiang, Yongwen,Ma, Dawei. "CuI/oxalamide catalyzed couplings of (hetero)aryl chlorides and phenols for diaryl ether formation". supporting information. p. 6211 - 6215. Retrieved 2016/05/24.