diethyl 2,2'-(4,5-bis{6-[(tert-butyldimethylsilyl)oxy]hex-1-ynyl}-1,2-phenylene)diacetate

Base Information

Chemical Name:diethyl 2,2'-(4,5-bis{6-[(tert-butyldimethylsilyl)oxy]hex-1-ynyl}-1,2-phenylene)diacetate
CAS No.:1443418-05-0
Molecular Formula:C₃₈H₆₂O₆Si₂
Molecular Weight:671.078
Hs Code.:

Synonyms:diethyl 2,2'-(4,5-bis{6-[(tert-butyldimethylsilyl)oxy]hex-1-ynyl}-1,2-phenylene)diacetate

Suppliers and Price of diethyl 2,2'-(4,5-bis{6-[(tert-butyldimethylsilyl)oxy]hex-1-ynyl}-1,2-phenylene)diacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl 2,2'-(4,5-bis{6-[(tert-butyldimethylsilyl)oxy]hex-1-ynyl}-1,2-phenylene)diacetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of diethyl 2,2'-(4,5-bis{6-[(tert-butyldimethylsilyl)oxy]hex-1-ynyl}-1,2-phenylene)diacetate

There total 8 articles about diethyl 2,2'-(4,5-bis{6-[(tert-butyldimethylsilyl)oxy]hex-1-ynyl}-1,2-phenylene)diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 18295-66-4
1-ethoxy-1-(trimethylsiloxy)ethene

: 1378950-68-5
4,5-bis[6-(tert-butyldimethylsilyloxy)hex-1-ynyl]-1,2-phenylene bis-(trifluoromethanesulfonate)

: 1443418-05-0
diethyl 2,2'-(4,5-bis{6-[(tert-butyldimethylsilyl)oxy]hex-1-ynyl}-1,2-phenylene)diacetate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium acetate; In tetrahydrofuran; at 70 ℃; for 5h; Inert atmosphere;
DOI:10.1002/ejoc.201201732

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1443418-05-0
diethyl 2,2'-(4,5-bis{6-[(tert-butyldimethylsilyl)oxy]hex-1-ynyl}-1,2-phenylene)diacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / dichloromethane / 1.5 h

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

3: lithium acetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 5 h / 70 °C / Inert atmosphere

With 1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium acetate; triethylamine; In tetrahydrofuran; dichloromethane; 2: |Sonogashira Cross-Coupling;
DOI:10.1002/ejoc.201201732

Reference yield:

: 73448-13-2
tert-butyldimethylsilyl hex-5-yn-1-yl ether

: 1443418-05-0
diethyl 2,2'-(4,5-bis{6-[(tert-butyldimethylsilyl)oxy]hex-1-ynyl}-1,2-phenylene)diacetate

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

2: lithium acetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 5 h / 70 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium acetate; triethylamine; In tetrahydrofuran; 1: |Sonogashira Cross-Coupling;
DOI:10.1002/ejoc.201201732