N-(tert-butoxycarbonyl)glycyl-N₁-(2-azidoethyl)-N₂-(4-methoxybenzyl)-2-methylalaninamide

Base Information

• Chemical Name: N-(tert-butoxycarbonyl)glycyl-N₁-(2-azidoethyl)-N₂-(4-methoxybenzyl)-2-methylalaninamide
• CAS No.: 1223636-22-3
• Molecular Formula: C₂₁H₃₂N₆O₅
• Molecular Weight: 448.522

Synonyms:N-(tert-butoxycarbonyl)glycyl-N₁-(2-azidoethyl)-N₂-(4-methoxybenzyl)-2-methylalaninamide

Chemical Property of N-(tert-butoxycarbonyl)glycyl-N₁-(2-azidoethyl)-N₂-(4-methoxybenzyl)-2-methylalaninamide

Chemical Property:

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Technology Process of N-(tert-butoxycarbonyl)glycyl-N₁-(2-azidoethyl)-N₂-(4-methoxybenzyl)-2-methylalaninamide

There total 1 articles about N-(tert-butoxycarbonyl)glycyl-N₁-(2-azidoethyl)-N₂-(4-methoxybenzyl)-2-methylalaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

1-azido-2-isocyanoethane (873975-41-8) + BOC-glycine (4530-20-5) + 4-methoxy-benzylamine (2393-23-9) + acetone (67-64-1) → N-(tert-butoxycarbonyl)glycyl-N1-(2-azidoethyl)-N2-(4-methoxybenzyl)-2-methylalaninamide (1223636-22-3)

Guidance literature:

In methanol; at 20 ℃; for 12h;

DOI:10.1002/ejoc.200901326

Reference yield: 75.0%

N-(tert-butoxycarbonyl)glycyl-N1-(2-azidoethyl)-N2-(4-methoxybenzyl)-2-methylalaninamide (1223636-22-3) + 1-phenoxy-2-propyne (13610-02-1) → N-[(1,1-dimethylethoxy)carbonyl]glycyl-N2-[(4-methoxyphenyl)methyl]-N1-[2-[4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl]ethyl]valinamide

Guidance literature:

With triethylphosphite copper(I) iodide complex; In ethanol; at 60 ℃; for 3h; regioselective reaction;

DOI:10.1002/ejoc.200901326

upstream raw materials:

1-azido-2-isocyanoethane

BOC-glycine

4-methoxy-benzylamine

acetone

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