(24R)-1α,25-dihydroxyvitamin D₂

Base Information

Chemical Name:(24R)-1α,25-dihydroxyvitamin D₂
CAS No.:95783-08-7
Molecular Formula:C₂₈H₄₄O₃
Molecular Weight:428.656
Hs Code.:

(24R)-1α,25-dihydroxyvitamin D<sub>2</sub>

Synonyms:(24R)-1α,25-dihydroxyvitamin D₂

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (24R)-1α,25-dihydroxyvitamin D₂

Chemical Property:

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Technology Process of (24R)-1α,25-dihydroxyvitamin D₂

There total 36 articles about (24R)-1α,25-dihydroxyvitamin D₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 114694-35-8
(E)-(3R,6R)-6-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-2,3-dimethyl-hept-4-en-2-ol

: 95783-08-7
(24R)-1α,25-dihydroxyvitamin D₂

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 50 ℃; for 0.833333h;
DOI:10.1021/jo00250a009

Reference yield:

: 73295-16-6
(R)-2,3-dimethyl-1,3-butanediol

: 95783-08-7
(24R)-1α,25-dihydroxyvitamin D₂

Guidance literature:: Multi-step reaction with 10 steps

1: pyridine / Ambient temperature

2: potassium t-butoxide / dimethylformamide / Ambient temperature

3: WO₃, 50percent NaOH, 30percent H₂O₂ / H₂O; ethanol / 0.67 h / 60 - 75 °C

4: 94 percent / PPTS / CH₂Cl₂ / 4 h / Ambient temperature

5: n-butyllithium / hexane; tetrahydrofuran / 1 h / -70 - -60 °C

6: Na₂HPO₄, 5percent sodium amalgam / methanol / 0 deg C, 15 h, then RT, 3 h

7: PPTS / aq. ethanol / 1 h / 50 °C

8: LiAlH₄ / tetrahydrofuran / 1.5 h / Heating

9: 28 percent / diethyl ether; tetrahydrofuran / 0.05 h / Irradiation

10: 42 percent / ethanol / 1 h / Heating

With pyridine; sodium hydroxide; disodium hydrogenphosphate; sodium amalgam; lithium aluminium tetrahydride; n-butyllithium; potassium tert-butylate; dihydrogen peroxide; tungsten(VI) oxide; pyridinium p-toluenesulfonate; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.62.3132

Reference yield:

: 114694-29-0
(R)-3-hydroxy-2,3-dimethylbutyl 4-methylbenzenesulfonate

: 95783-08-7
(24R)-1α,25-dihydroxyvitamin D₂

Guidance literature:: Multi-step reaction with 9 steps

1: potassium t-butoxide / dimethylformamide / Ambient temperature

2: WO₃, 50percent NaOH, 30percent H₂O₂ / H₂O; ethanol / 0.67 h / 60 - 75 °C

3: 94 percent / PPTS / CH₂Cl₂ / 4 h / Ambient temperature

4: n-butyllithium / hexane; tetrahydrofuran / 1 h / -70 - -60 °C

5: Na₂HPO₄, 5percent sodium amalgam / methanol / 0 deg C, 15 h, then RT, 3 h

6: PPTS / aq. ethanol / 1 h / 50 °C

7: LiAlH₄ / tetrahydrofuran / 1.5 h / Heating

8: 28 percent / diethyl ether; tetrahydrofuran / 0.05 h / Irradiation

9: 42 percent / ethanol / 1 h / Heating

With sodium hydroxide; disodium hydrogenphosphate; sodium amalgam; lithium aluminium tetrahydride; n-butyllithium; potassium tert-butylate; dihydrogen peroxide; tungsten(VI) oxide; pyridinium p-toluenesulfonate; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.62.3132