1-methyl-N-(4-((2-(morpholinomethyl)phenyl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

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Chemical Name:1-methyl-N-(4-((2-(morpholinomethyl)phenyl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
CAS No.:1374007-14-3
Molecular Formula:C₂₃H₂₃F₃N₄O₄S
Molecular Weight:508.521
Hs Code.:

Synonyms:1-methyl-N-(4-((2-(morpholinomethyl)phenyl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

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Chemical Property of 1-methyl-N-(4-((2-(morpholinomethyl)phenyl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

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Technology Process of 1-methyl-N-(4-((2-(morpholinomethyl)phenyl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

There total 9 articles about 1-methyl-N-(4-((2-(morpholinomethyl)phenyl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1393456-08-0
4-((2-(morpholinomethyl)phenyl)sulfonyl)aniline

: 128694-63-3
1-methyl-3-(trifluoromethyl)pyrazole-5-carboxylic acid

: 1374007-14-3
1-methyl-N-(4-((2-(morpholinomethyl)phenyl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: 1-methyl-3-(trifluoromethyl)pyrazole-5-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 ℃; for 1h;

4-((2-(morpholinomethyl)phenyl)sulfonyl)aniline; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 2h;
DOI:10.1021/jm201699w

Reference yield:

: 129768-24-7
1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride

: 110-91-8,99108-56-2
morpholine

: 1374007-06-3
C₁₃H₉NO₅S

: 1374007-14-3
1-methyl-N-(4-((2-(morpholinomethyl)phenyl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: morpholine; C₁₃H₉NO₅S; With sodium tris(acetoxy)borohydride; In dichloromethane;

With methanol; tin(ll) chloride; In dichloromethane;

1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

: 1374007-05-2
C₁₄H₁₁NO₄S

: 1374007-14-3
1-methyl-N-(4-((2-(morpholinomethyl)phenyl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium periodate; osmium(VIII) oxide; water / tetrahydrofuran / 40 h / 75 °C

2.1: sodium tris(acetoxy)borohydride / dichloromethane / 5 h

3.1: tin(II) chloride dihdyrate / methanol; dichloromethane

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 °C

4.2: 2 h

With sodium periodate; osmium(VIII) oxide; oxalyl dichloride; tin(II) chloride dihdyrate; water; sodium tris(acetoxy)borohydride; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm201699w