3(R)-benzyloxycarbonylamino-7-trifluoromethyl-2,3-dihydro-1,5(5H)-benzothiazepine-4-one

Base Information

Chemical Name:3(R)-benzyloxycarbonylamino-7-trifluoromethyl-2,3-dihydro-1,5(5H)-benzothiazepine-4-one
CAS No.:98413-36-6
Molecular Formula:C₁₈H₁₅F₃N₂O₃S
Molecular Weight:396.39
Hs Code.:

Synonyms:3(R)-benzyloxycarbonylamino-7-trifluoromethyl-2,3-dihydro-1,5(5H)-benzothiazepine-4-one

Suppliers and Price of 3(R)-benzyloxycarbonylamino-7-trifluoromethyl-2,3-dihydro-1,5(5H)-benzothiazepine-4-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of 3(R)-benzyloxycarbonylamino-7-trifluoromethyl-2,3-dihydro-1,5(5H)-benzothiazepine-4-one

Chemical Property:

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Technology Process of 3(R)-benzyloxycarbonylamino-7-trifluoromethyl-2,3-dihydro-1,5(5H)-benzothiazepine-4-one

There total 6 articles about 3(R)-benzyloxycarbonylamino-7-trifluoromethyl-2,3-dihydro-1,5(5H)-benzothiazepine-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 100236-30-4
S-(2-amino-4-trifluoromethylphenyl)-N-benzyloxycarbonyl-L-cysteine hydrochloride

: 98413-36-6
3(R)-benzyloxycarbonylamino-7-trifluoromethyl-2,3-dihydro-1,5(5H)-benzothiazepine-4-one

Guidance literature:: With triethylamine; diethyl dicarbonate; In N,N-dimethyl-formamide; 1) 0 deg C, 35 min. 2) r.t., 1 h;
DOI:10.1248/cpb.34.1128

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 98413-36-6
3(R)-benzyloxycarbonylamino-7-trifluoromethyl-2,3-dihydro-1,5(5H)-benzothiazepine-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / 2.5 N NaOH, HCl / H₂O / 3 h / 0 °C

2: 3.4 g / Zn, HCl / acetic acid; H₂O / 0.83 h

3: 42 percent / DEPC, Et₃N / dimethylformamide / 1) 0 deg C, 35 min. 2) r.t., 1 h

With hydrogenchloride; sodium hydroxide; triethylamine; diethyl dicarbonate; zinc; In water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.1128

Reference yield:

: 98413-16-2
(R)-2-Amino-3-(2-nitro-4-trifluoromethyl-phenylsulfanyl)-propionic acid

: 98413-36-6
3(R)-benzyloxycarbonylamino-7-trifluoromethyl-2,3-dihydro-1,5(5H)-benzothiazepine-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / 2.5 N NaOH, HCl / H₂O / 3 h / 0 °C

2: 3.4 g / Zn, HCl / acetic acid; H₂O / 0.83 h

3: 42 percent / DEPC, Et₃N / dimethylformamide / 1) 0 deg C, 35 min. 2) r.t., 1 h

With hydrogenchloride; sodium hydroxide; triethylamine; diethyl dicarbonate; zinc; In water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.1128