(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 4-(tert-butoxycarbonylamino)-2-methyl-5-phenylpent-2-enoate

Base Information

Chemical Name:(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 4-(tert-butoxycarbonylamino)-2-methyl-5-phenylpent-2-enoate
CAS No.:1174764-19-2
Molecular Formula:C₂₇H₄₁NO₄
Molecular Weight:443.627
Hs Code.:

Synonyms:(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 4-(tert-butoxycarbonylamino)-2-methyl-5-phenylpent-2-enoate

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Chemical Property of (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 4-(tert-butoxycarbonylamino)-2-methyl-5-phenylpent-2-enoate

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Technology Process of (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 4-(tert-butoxycarbonylamino)-2-methyl-5-phenylpent-2-enoate

There total 8 articles about (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 4-(tert-butoxycarbonylamino)-2-methyl-5-phenylpent-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1082984-76-6
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-(triphenylphosphoranylidene)propanoate

: 72155-45-4
Boc-L-phenylalaninal

: 1174764-19-2
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 4-(tert-butoxycarbonylamino)-2-methyl-5-phenylpent-2-enoate

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 8.25h; Inert atmosphere;
DOI:10.1039/c3ob27111k

Reference yield:

: 2216-51-5
(-)-menthol

: 1219930-73-0
(R)-phenylalanine

: 1174764-19-2
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 4-(tert-butoxycarbonylamino)-2-methyl-5-phenylpent-2-enoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In diethyl ether; at 0 ℃;

Reference yield:

: 2216-51-5
(-)-menthol

: 1174764-19-2
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 4-(tert-butoxycarbonylamino)-2-methyl-5-phenylpent-2-enoate

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2: tetrahydrofuran / 2.5 h / Inert atmosphere; Reflux

3: sodium hydroxide / water; toluene / 3.08 h / Inert atmosphere

4: sodium hydroxide / water; toluene / 3.08 h / Inert atmosphere

5: dichloromethane / 0 - 20 °C / Inert atmosphere

6: dichloromethane / 8.25 h / 0 - 20 °C / Inert atmosphere

With triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; toluene; 5: |Wittig Olefination / 6: |Wittig Olefination;
DOI:10.1039/c3ob27111k