4-(2-chloro-5-trifluoromethyl-phenoxy)-piperidine-1-carboxylic acid (2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-amide

Base Information

Chemical Name:4-(2-chloro-5-trifluoromethyl-phenoxy)-piperidine-1-carboxylic acid (2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-amide
CAS No.:1266245-57-1
Molecular Formula:C₁₈H₁₈ClF₃N₄O₃
Molecular Weight:430.814
Hs Code.:

Synonyms:4-(2-chloro-5-trifluoromethyl-phenoxy)-piperidine-1-carboxylic acid (2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-amide

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Chemical Property of 4-(2-chloro-5-trifluoromethyl-phenoxy)-piperidine-1-carboxylic acid (2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-amide

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Technology Process of 4-(2-chloro-5-trifluoromethyl-phenoxy)-piperidine-1-carboxylic acid (2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-amide

There total 4 articles about 4-(2-chloro-5-trifluoromethyl-phenoxy)-piperidine-1-carboxylic acid (2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1266244-49-8
4-(2-chloro-5-trifluoromethyl-phenoxy)-piperidine hydrochloride

: 7693-46-1
4-Nitrophenyl chloroformate

: 13563-36-5
2-methyl-4-amino-3(2H)-pyridazinone

: 1266245-57-1
4-(2-chloro-5-trifluoromethyl-phenoxy)-piperidine-1-carboxylic acid (2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-amide

Guidance literature:: 4-Nitrophenyl chloroformate; 2-methyl-4-amino-3(2H)-pyridazinone; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

4-(2-chloro-5-trifluoromethyl-phenoxy)-piperidine hydrochloride; With triethylamine; In tetrahydrofuran; at 50 ℃; for 24h;

Reference yield:

: 933-76-6
4,5-dichloro-2-methyl-3(2H)-pyridazinone

: 1266245-57-1
4-(2-chloro-5-trifluoromethyl-phenoxy)-piperidine-1-carboxylic acid (2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 20 - 70 °C

2.1: triethylamine; hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 48 h / 20 °C / 4500.45 Torr

3.1: hydrazine hydrate / 3 h / 80 °C

4.1: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

4.2: 24 h / 50 °C

With hydrogen; caesium carbonate; hydrazine hydrate; triethylamine; palladium 10% on activated carbon; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; toluene;

Reference yield:

: 1266244-68-1
C₁₁H₁₆ClN₃O₃

: 1266245-57-1
4-(2-chloro-5-trifluoromethyl-phenoxy)-piperidine-1-carboxylic acid (2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 48 h / 20 °C / 4500.45 Torr

2.1: hydrazine hydrate / 3 h / 80 °C

3.1: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3.2: 24 h / 50 °C

With hydrogen; hydrazine hydrate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran;