C₂₀H₁₉ClFN₅O₅

Base Information

• Chemical Name: C₂₀H₁₉ClFN₅O₅
• CAS No.: 1615696-41-7
• Molecular Formula: C₂₀H₁₉ClFN₅O₅
• Molecular Weight: 463.853

Synonyms:C₂₀H₁₉ClFN₅O₅

Chemical Property of C₂₀H₁₉ClFN₅O₅

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Technology Process of C₂₀H₁₉ClFN₅O₅

There total 7 articles about C₂₀H₁₉ClFN₅O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

C17H19FO7 (1615696-40-6) + 2-Amino-6-chloropurin (10310-21-1) → C20H19ClFN5O5 (1615696-41-7)

Guidance literature:

C₁₇H₁₉FO₇; 2-Amino-6-chloropurin; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

With trimethylsilyl trifluoromethanesulfonate; at 0 - 60 ℃; for 4h;

Reference yield: 70.0%

C17H19FO7 (1615696-40-6) + 2-amino-6-chloropurine (10310-21-1) → C20H19ClFN5O5 (1615696-41-7)

Guidance literature:

C₁₇H₁₉FO₇; 2-amino-6-chloropurine; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 0 - 60 ℃; for 4.5h; Inert atmosphere;

Reference yield:

C13H15FO4 (139546-24-0) → C20H19ClFN5O5 (1615696-41-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 12 h / -78 - 20 °C / Inert atmosphere

2.1: dmap; triethylamine / dichloromethane / 12 h / 20 °C / Cooling with ice

3.1: sulfuric acid / acetic acid / 12 h / 0 - 20 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.5 h / 0 - 20 °C / Inert atmosphere

4.2: 4 h / 0 - 60 °C

With dmap; sulfuric acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; dichloromethane; acetic acid; acetonitrile;

upstream raw materials:

C₂₁H₂₃FO₅

C₁₇H₁₉FO₇

2-Amino-6-chloropurin

C₁₃H₁₅FO₄

Downstream raw materials:

(2S)-neopentyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-ethoxy-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(2-chlorophenoxy)phosphoryl)amino)propanoate

(2S)-cyclohexyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-ethoxy-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(3-chloro-4-fluorophenoxy)phosphoryl)amino)propanoate

(2S)-neopentyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-ethoxy-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate

(2S)-cyclohexyl 2-(((((2R,3R,4S,5R)-5-(2-amino-6-ethoxy-1H-purin-9(6H)-yl)-3-fluoro-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate

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