(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid (4-carbamoyl-phenyl)-amide

Base Information

Chemical Name:(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid (4-carbamoyl-phenyl)-amide
CAS No.:1345866-72-9
Molecular Formula:C₃₀H₂₉Cl₂FN₄O₃
Molecular Weight:583.49
Hs Code.:

(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid (4-carbamoyl-phenyl)-amide

Synonyms:(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid (4-carbamoyl-phenyl)-amide

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Chemical Property of (2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid (4-carbamoyl-phenyl)-amide

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Technology Process of (2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid (4-carbamoyl-phenyl)-amide

There total 7 articles about (2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid (4-carbamoyl-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1345866-81-0
(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid (4-cyano-phenyl)-amide

: 1345866-72-9
(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid (4-carbamoyl-phenyl)-amide

Guidance literature:: With dihydrogen peroxide; sodium hydroxide; In water; dimethyl sulfoxide; at 0 ℃; for 0.25h;

Reference yield:

: 897365-76-3
(3E/Z)-6-chloro-3-(3-chloro-2-fluorobenzylidene)-1,3-dihydro-2H-indol-2-one

: 1345866-72-9
(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid (4-carbamoyl-phenyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene / 18 h / 80 °C

2.1: hydrogen / palladium dichloride / tetrahydrofuran; methanol / 18 h / 3102.97 Torr

2.2: 0.17 h / 20 °C

3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 20 °C

3.2: 20 °C / pH 5 - 6

4.1: N-ethyl-N,N-diisopropylamine; Diphenylphosphinic chloride / dichloromethane / 0.25 h / 20 °C

4.2: 18 h / 20 °C

5.1: sodium hydroxide; dihydrogen peroxide / water; dimethyl sulfoxide / 0.25 h / 0 °C

With water; hydrogen; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; sodium hydroxide; Diphenylphosphinic chloride; palladium dichloride; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; toluene;

Reference yield:

: 897365-81-0
(3S,3'S,4'R,6'R,8'S,8a'R)-6-chloro-8'-(3-chloro-2-fluorophenyl)-6'-neopentyl-3',4'-diphenyl-3',4',8',8a'-tetrahydrospiro[indoline-3,7'-pyrrolo[2,1-c][1,4]oxazine]-1',2(6'H)-dione

: 1345866-72-9
(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid (4-carbamoyl-phenyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium dichloride / tetrahydrofuran; methanol / 18 h / 3102.97 Torr

1.2: 0.17 h / 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 20 °C

2.2: 20 °C / pH 5 - 6

3.1: N-ethyl-N,N-diisopropylamine; Diphenylphosphinic chloride / dichloromethane / 0.25 h / 20 °C

3.2: 18 h / 20 °C

4.1: sodium hydroxide; dihydrogen peroxide / water; dimethyl sulfoxide / 0.25 h / 0 °C

With water; hydrogen; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; sodium hydroxide; Diphenylphosphinic chloride; palladium dichloride; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide;