897365-76-3

Usage

Uses

Used in Organic Synthesis:
2H-Indol-2-one, 6-chloro-3-[(3-chloro-2-fluorophenyl)Methylene]-1,3-dihydrois used as a building block in organic synthesis for the creation of various complex organic molecules. Its unique structure, which includes chlorine and fluorine atoms, allows for versatile chemical reactions and the formation of a wide range of compounds.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2H-Indol-2-one, 6-chloro-3-[(3-chloro-2-fluorophenyl)Methylene]-1,3-dihydrois used as a potential candidate for drug development. Its specific properties and the presence of heteroatoms may contribute to its biological activity, making it a promising compound for further research and development as a pharmaceutical agent.
Used in Pharmaceutical Applications:
2H-Indol-2-one, 6-chloro-3-[(3-chloro-2-fluorophenyl)Methylene]-1,3-dihydromay also be used in the development of pharmaceuticals, as its structure and potential biological activity could be harnessed to create new drugs or improve existing ones. Further research and testing would be necessary to determine its suitability and effectiveness in this application.

Upstream product

• 392332-35-3 6-chloro-2-oxindole 
• 85070-48-0 2-fluoro-3-chlorobenzaldehyde 
• 1174006-94-0 6-chloro-2-oxoindole 
• 56341-37-8 6-chloro-2-oxindole 
• 74444-81-8 5-chloro-1,3-dihydro-2H-inden-2-one 

Downstream Products

• 897365-81-0 (3S,3'S,4'R,6'R,8'S,8a'R)-6-chloro-8'-(3-chloro-2-fluorophenyl)-6'-neopentyl-3',4'-diphenyl-3',4',8',8a'-tetrahydrospiro[indoline-3,7'-pyrrolo[2,1-c][1,4]oxazine]-1',2(6'H)-dione 
• 1303607-07-9 (2'R,3S,3'S,5'R)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide 
• 1303609-27-9 C₄₈H₅₈Cl₂FN₃O₄Si 
• 1303606-44-1 (2′R,3S,4′R,5′R)-6-chloro-4′-(3-chlorophenyl)-N-((1s,3S)-3-hydroxy-3-methylcyclobutyl)-2′-neopentyl-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxamide trifluoroacetic acid 
• 1303609-29-1 MI-519-65-TFA 
• 1303609-28-0 C₄₈H₅₈Cl₂FN₃O₄Si 
• 1303609-36-0 C₄₃H₄₆Cl₂FN₃O₄ 
• 1303609-37-1 (2'R,3S,4'S,5R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-(trans-4-hydroxycyclohexyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide trifluoroacetate 
• 1303606-45-2 (2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid tert-butyl ester 
• 1345866-81-0 (2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid (4-cyano-phenyl)-amide 
• 1345866-72-9 (2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid (4-carbamoyl-phenyl)-amide 
• 1345866-74-1 (2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid [4-(2-hydroxy-ethoxy)-2-methoxy-phenyl]-amide 
• 1345866-82-1 (2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid (4-cyano-2-methoxy-phenyl)-amide 
• 1345866-75-2 (2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid (4-carbamoyl-2-methoxy-phenyl)-amide 

Relevant academic research and scientific papers

Copper(i)/Ganphos catalysis: enantioselective synthesis of diverse spirooxindoles using iminoesters and alkyl substituted methyleneindolinones

A copper-catalyzed asymmetric 1,3-dipolar cycloaddition of glycine iminoesters with alkyl substituted 3-methylene-2-oxindoles is described. By usingde novodesign of P-stereogenic phosphines as ligands, spiro[pyrrolidin-3,3'-oxindole]s are generated in good to excellent yields with high asymmetric induction. A further reduced catalyst loading of 0.1 mol% is sufficient to achieve a satisfactory enantioselectivity of 90% ee. The DFT calculations suggest the second Michael addition of the 1,3-dipole to be the rate- andenantio-determining step. A key feature of this 1,3-dipolar cycloaddition is the wide substrate applicability, even with alkyl aldehyde-derived azomethine ylide; thus it has streamlined a highly enantioselective access to a new class of antiproliferative agents, MDM2-p53.

Phosphine-catalyzed synthesis of 3,3-spirocyclopenteneoxindoles from γ-substituted allenoates: Systematic studies and targeted applications

The phosphine-promoted [3 + 2] cyclizations between γ-substituted allenoates and arylideneoxindoles have been applied to the stereoselective synthesis of spiro(cyclopentene)oxindoles with trisubstituted cyclopentene units. It has been demonstrated that PP

Substituted Spiro[3H-Indole-3,6'(5'H)-[1H]Pyrrolo[1,2c]Imidazole-1',2(1H,2'H)-diones

There are provided compounds of the formula wherein X, Y, R1, R1′, R2, R2′, R3, R4, R5 and R6 are as described herein and enantiomers or a pharmaceutically acceptable salt or ester thereof. The compounds are useful as anticancer agents.

SPIROINDOLINONE PYRROLIDINES

There are provided compounds of the formula wherein X, Y and R1 to R8 are described herein along with the enantiomers, pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.

SPIROINDOLINONE PYRROLIDINES

There are provided compounds of the formula (I) wherein X, Y and R1 to R8 are as described herein, their enantiomers and pharmaceutically acceptable salts and esters, as well as processes for making these compounds and medicaments containing them.

SPIRO-OXINDOLE MDM2 ANTAGONISTS

Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as

SPIROINDOLINONE DERIVATIVES

There are provided compounds of the general formulas wherein X, Y, R1, R2, R3 and R4 are as described herein. The compounds exhibit anticancer activity.