(6-methoxy-2-phenyl-1,2,3,4-tetrahydro-quinolin-4-yl)-carbamic acid benzyl ester

Base Information

• Chemical Name: (6-methoxy-2-phenyl-1,2,3,4-tetrahydro-quinolin-4-yl)-carbamic acid benzyl ester
• CAS No.: 1140966-18-2
• Molecular Formula: C₂₄H₂₄N₂O₃
• Molecular Weight: 388.466
• Mol file: 1140966-18-2.mol

Synonyms:(6-methoxy-2-phenyl-1,2,3,4-tetrahydro-quinolin-4-yl)-carbamic acid benzyl ester

Chemical Property of (6-methoxy-2-phenyl-1,2,3,4-tetrahydro-quinolin-4-yl)-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (6-methoxy-2-phenyl-1,2,3,4-tetrahydro-quinolin-4-yl)-carbamic acid benzyl ester

There total 5 articles about (6-methoxy-2-phenyl-1,2,3,4-tetrahydro-quinolin-4-yl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

benzyl N-vinylcarbamate (84713-20-2) + benzaldehyde (100-52-7) + 4-methoxy-aniline (104-94-9) → (6-methoxy-2-phenyl-1,2,3,4-tetrahydro-quinolin-4-yl)-carbamic acid benzyl ester (1140966-18-2)

Guidance literature:

benzaldehyde; 4-methoxy-aniline; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

benzyl N-vinylcarbamate; With (S)-6,6'-bis(4-chlorophenyl)-1,1'-spirobiindane-7,7'-diyl phosphate; In dichloromethane; at -20 ℃; for 2h; enantioselective reaction; Inert atmosphere;

DOI:10.1039/c2ra22796g

Reference yield: 79.0%

benzyl N-vinylcarbamate (84713-20-2) + [4-(benzylideneamino)phenyl]methanol (783-08-4) → (6-methoxy-2-phenyl-1,2,3,4-tetrahydro-quinolin-4-yl)-carbamic acid benzyl ester (1140966-18-2)

Guidance literature:

With (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; magnesium sulfate; In toluene; at 40 ℃; for 72h; stereoselective reaction; Inert atmosphere;

DOI:10.1002/adsc.201701484

Reference yield: 21.0%

ethanol (64-17-5) + benzyl N-vinylcarbamate (84713-20-2) + benzaldehyde (100-52-7) + 4-methoxy-aniline (104-94-9) → (6-methoxy-2-phenyl-1,2,3,4-tetrahydro-quinolin-4-yl)-carbamic acid benzyl ester (1140966-18-2) + C26H30N2O4

Guidance literature:

ethanol; benzaldehyde; 4-methoxy-aniline; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

benzyl N-vinylcarbamate; With (R)-2,6-bis-(4-chloro-phenyl)-4-oxo-3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-ol; In dichloromethane; at 0 ℃; for 24h; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ol9023985

upstream raw materials:

benzyl N-vinylcarbamate

[4-(benzylideneamino)phenyl]methanol

ethanol

benzaldehyde