1-Ethoxy-2,2-difluoro-1-propanol

Base Information

• Chemical Name: 1-Ethoxy-2,2-difluoro-1-propanol
• CAS No.: 165544-23-0
• Molecular Formula: C₅H₁₀F₂O₂
• Molecular Weight: 140.13
• DSSTox Substance ID: DTXSID501302317
• Nikkaji Number: J681.089F

Synonyms:1-ethoxy-2,2-difluoro-1-propanol;165544-23-0;SCHEMBL4192052;DTXSID501302317

Chemical Property of 1-Ethoxy-2,2-difluoro-1-propanol

Chemical Property:

• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 140.06488588
• Heavy Atom Count: 9
• Complexity: 85

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC(C(C)(F)F)O

Technology Process of 1-Ethoxy-2,2-difluoro-1-propanol

There total 2 articles about 1-Ethoxy-2,2-difluoro-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

ethyl 2,2-difluoropropanoate (28781-85-3) → 2,2-Difluoro-1-methoxy-1-propanol (165544-26-3) + 1-Ethoxy-2,2-difluoro-1-propanol (165544-23-0)

Guidance literature:

With methanol; sodium tetrahydroborate;

Reference yield:

methanol (67-56-1) + ethyl 2,2-difluoropropanoate (28781-85-3) → 2,2-Difluoro-1-methoxy-1-propanol (165544-26-3) + 1-Ethoxy-2,2-difluoro-1-propanol (165544-23-0)

Guidance literature:

With sodium tetrahydroborate; at -50 - -45 ℃; for 1h; Title compound not separated from byproducts;

DOI:10.1021/jo00121a040

Reference yield:

4-methoxy-aniline (104-94-9) + 2,2-Difluoro-1-methoxy-1-propanol (165544-26-3) + 1-Ethoxy-2,2-difluoro-1-propanol (165544-23-0) → N-(2,2-difluoropropylidene)-4-methoxyaniline

Guidance literature:

In toluene; for 3h; Heating / reflux;

upstream raw materials:

methanol

ethyl 2,2-difluoropropanoate

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