Technology Process of (5α,24R)-3β-acetoxy-24-benzoyloxy-7-β-hydroxycholestane
There total 7 articles about (5α,24R)-3β-acetoxy-24-benzoyloxy-7-β-hydroxycholestane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
platinum(IV) oxide;
In
ethyl acetate;
at 20 ℃;
for 3h;
atmospheric pressure;
DOI:10.1248/cpb.51.1177
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: pyridine
2.1: aq. AD-mix-β / 2-methyl-propan-2-ol
3.1: 93 percent / pyridine / 20 °C
4.1: 86 percent / pyridine; POCl3 / 12 h / 20 °C
5.1: 63 percent / H2 / Pd/C / ethyl acetate / 3 h / 20 °C / atmospheric pressure
6.1: N-hydroxyphthalamide; benzoyl peroxide; air / ethyl acetate; acetone / 48 h / 50 - 60 °C
6.2: 64 percent / pyridine; Ac2O / 12 h / 20 °C
7.1: 23 percent / H2 / PtO2 / ethyl acetate / 3 h / 20 °C / atmospheric pressure
With
pyridine; air; N-hydroxyphthalamide; AD-mix-β; hydrogen; trichlorophosphate; dibenzoyl peroxide;
platinum(IV) oxide; palladium on activated charcoal;
In
ethyl acetate; acetone; tert-butyl alcohol;
2.1: Sharpless asymmetric dihydroxylation;
DOI:10.1248/cpb.51.1177
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: aq. AD-mix-β / 2-methyl-propan-2-ol
2.1: 93 percent / pyridine / 20 °C
3.1: 86 percent / pyridine; POCl3 / 12 h / 20 °C
4.1: 63 percent / H2 / Pd/C / ethyl acetate / 3 h / 20 °C / atmospheric pressure
5.1: N-hydroxyphthalamide; benzoyl peroxide; air / ethyl acetate; acetone / 48 h / 50 - 60 °C
5.2: 64 percent / pyridine; Ac2O / 12 h / 20 °C
6.1: 23 percent / H2 / PtO2 / ethyl acetate / 3 h / 20 °C / atmospheric pressure
With
pyridine; air; N-hydroxyphthalamide; AD-mix-β; hydrogen; trichlorophosphate; dibenzoyl peroxide;
platinum(IV) oxide; palladium on activated charcoal;
In
ethyl acetate; acetone; tert-butyl alcohol;
1.1: Sharpless asymmetric dihydroxylation;
DOI:10.1248/cpb.51.1177
