N'-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Base Information

Chemical Name:N'-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
CAS No.:1221443-13-5
Molecular Formula:C₃₆H₃₆F₂N₄O₆
Molecular Weight:658.702
Hs Code.:

N'-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Synonyms:N'-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

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Chemical Property of N'-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

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Technology Process of N'-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

There total 7 articles about N'-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 849217-50-1
N-[3-fluoro-4-[[7-hydroxy-6-methoxy-quinolin-4-yl]oxy]phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

: 1221443-41-9
3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propyl methanesulfonate

: 1221443-13-5
N'-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:: With caesium carbonate; In N,N-dimethyl acetamide; at 20 ℃; for 48h; Inert atmosphere;

Reference yield:

: 1221443-39-5
5-((R)-α-methylbenzyl)-7-hydroxy-5-azaspiro[2.4]heptane

: 1221443-13-5
N'-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium on activated charcoal / ethanol / 3 h

2: triethylamine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0 °C / Inert atmosphere

4: caesium carbonate / N,N-dimethyl acetamide / 48 h / 20 °C / Inert atmosphere

With hydrogen; caesium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide;

Reference yield:

: 32933-03-2
ethyl 1-acetylcyclopropanecarboxylate

: 1221443-13-5
N'-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: N-Bromosuccinimide / toluene-4-sulfonic acid / 8 h / 20 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

3: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 0 - 50 °C / Inert atmosphere

4: hydrogen / palladium on activated charcoal / ethanol / 3 h

5: triethylamine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

6: triethylamine / dichloromethane / 0 °C / Inert atmosphere

7: caesium carbonate / N,N-dimethyl acetamide / 48 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; lithium aluminium tetrahydride; hydrogen; caesium carbonate; triethylamine; palladium on activated charcoal; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide;