1-(3-amino-2-methyl-4-(trifluoromethyl)phenyl)-3-cyclopropyl-propane-1,3-dione

Base Information

Chemical Name:1-(3-amino-2-methyl-4-(trifluoromethyl)phenyl)-3-cyclopropyl-propane-1,3-dione
CAS No.:1263093-14-6
Molecular Formula:C₁₄H₁₄F₃NO₂
Molecular Weight:285.266
Hs Code.:

Synonyms:1-(3-amino-2-methyl-4-(trifluoromethyl)phenyl)-3-cyclopropyl-propane-1,3-dione

Suppliers and Price of 1-(3-amino-2-methyl-4-(trifluoromethyl)phenyl)-3-cyclopropyl-propane-1,3-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 1-(3-amino-2-methyl-4-(trifluoromethyl)phenyl)-3-cyclopropyl-propane-1,3-dione

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(3-amino-2-methyl-4-(trifluoromethyl)phenyl)-3-cyclopropyl-propane-1,3-dione

There total 8 articles about 1-(3-amino-2-methyl-4-(trifluoromethyl)phenyl)-3-cyclopropyl-propane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1263093-13-5
tert-butyl 2-(3-amino-2-methyl-4-(trifluoromethyl)benzoyl)-3-cyclopropyl-3-oxopropanoate

: 1263093-14-6
1-(3-amino-2-methyl-4-(trifluoromethyl)phenyl)-3-cyclopropyl-propane-1,3-dione

Guidance literature:: With trifluoroacetic acid; Reflux;

Reference yield:

: 1263093-09-9
2-[3-fluoro-4-(trifluoromethyl)phenyl]-4,4-dimethyl-5H-oxazole

: 1263093-14-6
1-(3-amino-2-methyl-4-(trifluoromethyl)phenyl)-3-cyclopropyl-propane-1,3-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / n-heptane; tetrahydrofuran / -70 - -62 °C / Inert atmosphere

1.2: -70 - 20 °C

2.1: potassium tert-butylate / ISOPROPYLAMIDE / 0.08 h

2.2: 0.75 h / 140 °C

3.1: hydrogenchloride / water / 4 h / Reflux

4.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / tetrahydrofuran / 22 h / 0 - 20 °C

4.2: 20 °C

5.1: trifluoroacetic acid / Reflux

With hydrogenchloride; n-butyllithium; potassium tert-butylate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In tetrahydrofuran; n-heptane; ISOPROPYLAMIDE; water;

Reference yield:

: 216144-68-2
3-fluoro-4-(trifluoromethyl)benzoyl chloride

: 1263093-14-6
1-(3-amino-2-methyl-4-(trifluoromethyl)phenyl)-3-cyclopropyl-propane-1,3-dione

Guidance literature:: Multi-step reaction with 7 steps

1.1: dichloromethane / 17.5 h / 5 - 25 °C

2.1: thionyl chloride / dichloromethane / 5 h / 20 °C

3.1: n-butyllithium / n-heptane; tetrahydrofuran / -70 - -62 °C / Inert atmosphere

3.2: -70 - 20 °C

4.1: potassium tert-butylate / ISOPROPYLAMIDE / 0.08 h

4.2: 0.75 h / 140 °C

5.1: hydrogenchloride / water / 4 h / Reflux

6.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / tetrahydrofuran / 22 h / 0 - 20 °C

6.2: 20 °C

7.1: trifluoroacetic acid / Reflux

With hydrogenchloride; n-butyllithium; thionyl chloride; potassium tert-butylate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In tetrahydrofuran; n-heptane; dichloromethane; ISOPROPYLAMIDE; water;