2-Nitro-N-[1-(pyridin-4-yl)piperidin-4-ylmethoxycarbonyl)benzeneamine

Base Information

• Chemical Name: 2-Nitro-N-[1-(pyridin-4-yl)piperidin-4-ylmethoxycarbonyl)benzeneamine
• CAS No.: 219491-85-7
• Molecular Formula: C₁₈H₂₀N₄O₄
• Molecular Weight: 356.381
• Mol file: 219491-85-7.mol

Synonyms:2-Nitro-N-[1-(pyridin-4-yl)piperidin-4-ylmethoxycarbonyl)benzeneamine

Chemical Property of 2-Nitro-N-[1-(pyridin-4-yl)piperidin-4-ylmethoxycarbonyl)benzeneamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Nitro-N-[1-(pyridin-4-yl)piperidin-4-ylmethoxycarbonyl)benzeneamine

There total 4 articles about 2-Nitro-N-[1-(pyridin-4-yl)piperidin-4-ylmethoxycarbonyl)benzeneamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-nitrophenyl isocyanate (3320-86-3) + 4-hydroxymethyl-1-(pyridin-4-yl)piperidine (130658-67-2) → 2-Nitro-N-[1-(pyridin-4-yl)piperidin-4-ylmethoxycarbonyl)benzeneamine (219491-85-7)

Guidance literature:

In tetrahydrofuran; chloroform;

DOI:10.1016/j.bmcl.2005.07.030

Reference yield:

1-(pyridin-4-yl)piperidine-4-carboxylic acid ethyl ester (121912-29-6) → 2-Nitro-N-[1-(pyridin-4-yl)piperidin-4-ylmethoxycarbonyl)benzeneamine (219491-85-7)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran

2: CHCl₃; tetrahydrofuran

With lithium aluminium tetrahydride; In tetrahydrofuran; chloroform;

DOI:10.1016/j.bmcl.2005.07.030

Reference yield:

4-carbethoxypiperidine (1126-09-6) → 2-Nitro-N-[1-(pyridin-4-yl)piperidin-4-ylmethoxycarbonyl)benzeneamine (219491-85-7)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / ethanol / 48 h / 120 °C

2: LiAlH₄ / tetrahydrofuran

3: CHCl₃; tetrahydrofuran

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; ethanol; chloroform;

DOI:10.1016/j.bmcl.2005.07.030

upstream raw materials:

2-nitrophenyl isocyanate

4-hydroxymethyl-1-(pyridin-4-yl)piperidine

4-carbethoxypiperidine

4-chlorpyridine hydrochloride

Downstream raw materials:

N₁-[[1-(4-pyridyl)piperidin-4-yl]methoxycarbonyl]-1,2-benzenediamine