(1-(Pyridin-2-yl)piperidin-4-yl)methanol

Base Information

• Chemical Name: (1-(Pyridin-2-yl)piperidin-4-yl)methanol
• CAS No.: 130658-67-2
• Molecular Formula: C11H16 N2 O
• Molecular Weight: 192.261
• European Community (EC) Number: 817-228-9
• DSSTox Substance ID: DTXSID10444678
• Wikidata: Q82262894
• Mol file: 130658-67-2.mol

Synonyms:(1-(pyridin-2-yl)piperidin-4-yl)methanol;199117-79-8;[1-(pyridin-2-yl)piperidin-4-yl]methanol;(1-pyridin-2-ylpiperidin-4-yl)methanol;4-Piperidinemethanol,1-(4-pyridinyl)-;SCHEMBL8326977;DTXSID10444678;GVAWIUOVSIOZFQ-UHFFFAOYSA-N;N-(2-Pyridyl)-4-piperidinemethanol;AKOS010190567;4-Hydroxymethyl-1-(pyridin-2-yl) piperidine;EN300-136863;Z645232550

Chemical Property of (1-(Pyridin-2-yl)piperidin-4-yl)methanol

Chemical Property:

• PSA: 36.36000
• LogP: 1.35530
• Storage Temp.: 2-8°C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 192.126263138
• Heavy Atom Count: 14
• Complexity: 167

Purity/Quality:

97% ^*data from raw suppliers

(3,4,5,6-Tetrahydro-2H-1,4bipyridinyl-4-yl)-methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCC1CO)C2=CC=CC=N2

Technology Process of (1-(Pyridin-2-yl)piperidin-4-yl)methanol

There total 9 articles about (1-(Pyridin-2-yl)piperidin-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

1-(pyridin-4-yl)piperidine-4-carboxylic acid ethyl ester (121912-29-6) → 4-hydroxymethyl-1-(pyridin-4-yl)piperidine (130658-67-2)

Guidance literature:

1-(pyridin-4-yl)piperidine-4-carboxylic acid ethyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 4h; Cooling with ice;

With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; Cooling with ice;

Reference yield:

methyl N-(pyridin-4-yl)isonipecotate (219493-02-4) + sodium tartrate (868-18-8) + potassium tartrate → N-(5-chloropyridin-2-yl)-2-[[1-(4-pyridinyl)piperidin-4-yl]methoxy]benzamide (725683-58-9) + 4-hydroxymethyl-1-(pyridin-4-yl)piperidine (130658-67-2)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

methyl N-(pyridin-4-yl)isonipecotate (219493-02-4) + sodium tartrate (868-18-8) + potassium tartrate → 4-hydroxymethyl-1-(pyridin-4-yl)piperidine (130658-67-2)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; ethyl acetate;

upstream raw materials:

1-(pyridin-4-yl)piperidine-4-carboxylic acid ethyl ester

4-carboxy-N-(4'-pyridino) piperidine

4-carbethoxypiperidine

4-chlorpyridine hydrochloride

Downstream raw materials:

2-Nitro-N-[1-(pyridin-4-yl)piperidin-4-ylmethoxycarbonyl)benzeneamine

N₁-[[1-(4-pyridyl)piperidin-4-yl]methoxycarbonyl]-1,2-benzenediamine

4-[(6-chloro-2-naphthalenyl)sulfonyl]-6-oxo-1-[[1-(4-pyridinyl)-4-piperidinyl]methyl]-2-piperazinecarboxylic acid

(R)-4-[(6-chloro-2-naphthalenyl)sulfonyl]-6-oxo-1-[[1-(4-pyridinyl)-4-piperidinyl]methyl]-2-piperazinecarbocylic acid